Alzheimer genetics
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Alzheimer's disease (AD) often has a complex genetic architecture. Until late 2013, only 10 genes had consistently been implicated as risk genes for AD:
Number | Gene |
1. | ApoE-ε4 |
2. | BIN1 |
3. | CLU |
4. | ABCA7 |
5. | CR1 |
6. | PICALM |
7. | MS4A6A |
8. | CD33 |
9. | MS4A6E |
10. | CD2AP |
source alzgene.org [[1]]
The above table tends to order the SNPs by size of Odds ratios
Also SNPs in other genes with large effect have been discovered:
1. | TREM2 |
2. | PLD3 |
Many genes have recently been linked to Alzheimer's in a large study called the International Genomics of Alzheimer's Project (IGAP).
(b) These are newly confirmed AD genes in IGAP.
number | Gene |
1. | CASS4 |
2. | CELF1 |
3. | FERMT2 |
4. | HLA |
5. | INPP5D |
6. | MEF2C |
7. | NME8 |
8. | PTK2B |
9. | SLC24A4 |
10 | SORL1 |
11. | ZCWPW1 |
TREML2 and TRIP4 have now been confirmed AD SNPs.
Number | Gene |
1. | TREML2 |
2. | TRIP4 |
(d) These are suggestive AD genes from IGAP that are yet to be confirmed.
Number | Gene |
1. | SPPL2A |
2. | ECHDC3 |
3. | NDUFAF6 |
4. | ADAMST20 |
5. | SCIMP |
6. | AP2A2 |
7. | HS3ST1 |
8. | SQSTM1 |
9. | IGH |
10. | ACE |