Difference between revisions of "Enhance autophagy, ketogenesis"
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[http://en.wikipedia.org/wiki/Ketogenesis Ketogenesis] means making ketone molecules. When you sleep, after your last meal with carbs is all digested and used, your brain still needs energy. If you fast long enough it gets some from turning your fat stores into ketones which the brain loves. | [http://en.wikipedia.org/wiki/Ketogenesis Ketogenesis] means making ketone molecules. When you sleep, after your last meal with carbs is all digested and used, your brain still needs energy. If you fast long enough it gets some from turning your fat stores into ketones which the brain loves. | ||
[http://en.wikipedia.org/wiki/Insulin] | [http://en.wikipedia.org/wiki/Insulin Insulin] is the hormone produced when you eat carbs, telling your body to take glucose out of the bloodstream. If you eat too many carbs over decades your body can become insulin resistant. You become diabetic, which doubles your Alzheimer's risk. | ||
Aß ([http://en.wikipedia.org/wiki/Amyloid_beta Amyloid Beta]) plaque is often found in autopsies of Alzheimer's brains. A ketogenic diet has been shown to reduce the plaques in [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1282589/ mice]. | Aß ([http://en.wikipedia.org/wiki/Amyloid_beta Amyloid Beta]) plaque is often found in autopsies of Alzheimer's brains. A ketogenic diet has been shown to reduce the plaques in [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1282589/ mice]. | ||
Pieces of Aß are [http://www.jneurosci.org/content/22/10/RC221.full.pdf insulin-like] molecules that make it harder for brain cells to get glucose from the blood. | Pieces of Aß are [http://www.jneurosci.org/content/22/10/RC221.full.pdf insulin-like] molecules that make it harder for brain cells to get glucose from the blood. | ||
'''References''' | |||
Overnight fasting/autophagy as a neuroprotective strategy: | Overnight fasting/autophagy as a neuroprotective strategy: | ||
Neuroprotective effects of dietary restriction: Evidence and mechanisms | Neuroprotective effects of dietary restriction: Evidence and mechanisms. | ||
http://www.ncbi.nlm.nih.gov/pubmed/25773162 | http://www.ncbi.nlm.nih.gov/pubmed/25773162 | ||
Ketone as an alternate form of neural fuel in ApoE4 carriers: | Ketone as an alternate form of neural fuel in ApoE4 carriers: | ||
Brain fuel metabolism, aging, and Alzheimer's disease | Brain fuel metabolism, aging, and Alzheimer's disease. | ||
http://www.ncbi.nlm.nih.gov/pubmed/21035308 | http://www.ncbi.nlm.nih.gov/pubmed/21035308 | ||
The next intervention is [[Reduce stress]]. | The next intervention is [[Reduce stress]]. |
Revision as of 13:24, 14 May 2016
The second intervention to reverse mild Alzheimer's in the Bredesen Protocol Explained is:
- Goal: Enhance autophagy, ketogenesis
- Approach: Fast 12 hr each night, including 3 hr prior to bedtime.
- Rationale: Reduce insulin levels, reduce Aß.
Autophagy means self-eating. When you don't eat for long periods, your body turns to itself for fuel and spare parts, hopefully mostly eating things that are messed up anyways and need to be gotten rid of.
Ketogenesis means making ketone molecules. When you sleep, after your last meal with carbs is all digested and used, your brain still needs energy. If you fast long enough it gets some from turning your fat stores into ketones which the brain loves.
Insulin is the hormone produced when you eat carbs, telling your body to take glucose out of the bloodstream. If you eat too many carbs over decades your body can become insulin resistant. You become diabetic, which doubles your Alzheimer's risk.
Aß (Amyloid Beta) plaque is often found in autopsies of Alzheimer's brains. A ketogenic diet has been shown to reduce the plaques in mice. Pieces of Aß are insulin-like molecules that make it harder for brain cells to get glucose from the blood.
References
Overnight fasting/autophagy as a neuroprotective strategy: Neuroprotective effects of dietary restriction: Evidence and mechanisms.
http://www.ncbi.nlm.nih.gov/pubmed/25773162
Ketone as an alternate form of neural fuel in ApoE4 carriers: Brain fuel metabolism, aging, and Alzheimer's disease.
http://www.ncbi.nlm.nih.gov/pubmed/21035308
The next intervention is Reduce stress.