Difference between revisions of "Optimize mitochondrial function"
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[http://alzdiscovery.org/cognitive-vitality/report/ala a-lipoic acid] can reduce the formation of Alzheimer's disease plaques and increase the production of acetylcholine, an important signaling molecule that is impaired in Alzheimer's disease. | [http://alzdiscovery.org/cognitive-vitality/report/ala a-lipoic acid] can reduce the formation of Alzheimer's disease plaques and increase the production of acetylcholine, an important signaling molecule that is impaired in Alzheimer's disease. | ||
PQQ | PQQ ([http://en.wikipedia.org/wiki/Pyrroloquinoline_quinone pyrroloquinoline quinone]) [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212345/ prevents] cognitive deficit caused by oxidative stress in rats | ||
NAC ([http://onlinelibrary.wiley.com/doi/10.1002/brb3.208/full N-acetylcysteine]) 400-500mg (to increase glutathione cellular protection) blocks oxidative damage in Alzheimer's. | NAC ([http://onlinelibrary.wiley.com/doi/10.1002/brb3.208/full N-acetylcysteine]) 400-500mg (to increase glutathione cellular protection) blocks oxidative damage in Alzheimer's. | ||
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Alzheimer's patients with low Se ([http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147716/ Selenium]) in their blood have been found to have more problems with cognitive function. | Alzheimer's patients with low Se ([http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147716/ Selenium]) in their blood have been found to have more problems with cognitive function. | ||
Zn | [[Optimize Zn:fCu ratio]] | ||
[http://en.wikipedia.org/wiki/Resveratrol Resveratrol] [http://www.medscape.com/viewarticle/851172 Stabilizes Amyloid in Alzheimer's] | |||
Blood brain barrier dysfunction accelerates the rate of degeneration in Alzheimer's by impairing the ability of the brain to concentrate ascorbate ([http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2674290/ Vitamin C]) and other nutrients with neuroprotective properties. | Blood brain barrier dysfunction accelerates the rate of degeneration in Alzheimer's by impairing the ability of the brain to concentrate ascorbate ([http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2674290/ Vitamin C]) and other nutrients with neuroprotective properties. | ||
thiamine | [http://en.wikipedia.org/wiki/Thiamine Thiamine] 2.5mg. Oral thiamine trials have been [http://www.ncbi.nlm.nih.gov/pubmed/22218733 shown] to improve the cognitive function of patients with AD. | ||
The next intervention is [[Increase focus]]. | The next intervention is [[Increase focus]]. | ||
Revision as of 17:48, 14 June 2016
The twenty first intervention to reverse mild Alzheimer's in the Bredesen Protocol is:
- Goal: Optimize mitochondrial function
- Approach: CoQ or ubiquinol, a-lipoic acid, PQQ, NAC, ALCAR, Se, Zn, resveratrol, ascorbate, thiamine
- References: The Disease Delusion: Conquering the Causes of Illness for a Healthier, Longer and Happier Life
- Improving and Retaining Memory Function Feb 15, 2015
Mitochondria are the organelles in your cells that generate energy. CoQ Coenzyme Q10 is a molecule in the mitochondria that is essential to producing energy. Ubiquinol is it's electron-rich (reduced) form that is better absorbed.
a-lipoic acid can reduce the formation of Alzheimer's disease plaques and increase the production of acetylcholine, an important signaling molecule that is impaired in Alzheimer's disease.
PQQ (pyrroloquinoline quinone) prevents cognitive deficit caused by oxidative stress in rats
NAC (N-acetylcysteine) 400-500mg (to increase glutathione cellular protection) blocks oxidative damage in Alzheimer's.
Acetyl-L-carnitine (ALCAR) 500mg per day.
Alzheimer's patients with low Se (Selenium) in their blood have been found to have more problems with cognitive function.
Resveratrol Stabilizes Amyloid in Alzheimer's
Blood brain barrier dysfunction accelerates the rate of degeneration in Alzheimer's by impairing the ability of the brain to concentrate ascorbate (Vitamin C) and other nutrients with neuroprotective properties.
Thiamine 2.5mg. Oral thiamine trials have been shown to improve the cognitive function of patients with AD.
The next intervention is Increase focus.