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- 12:08, 7 April 2024 diff hist +836 Insulin Resistance in the brain →A deeper dive into the science: added paper:[https://www.nature.com/articles/s42255-024-01007-w '''Insulin signalling regulates Pink1 mRNA localization via modulation of AMPK activity to support PINK1 function in neurons(J. Tabitha Hees et al, 19 Mar 2024) current
- 08:26, 7 April 2024 diff hist +807 Mitochondria →Other research on mitochondria and Alzheimer’s Disease: added paper: Enhanced mitochondrial fusion during a critical period of synaptic plasticity in adult-born neurons (Sandra M.V. Kochan et al, 5 Apr 2024) current
- 16:27, 4 April 2024 diff hist +656 Fats, Omega -3(ω-3) & -6(ω-6), DHA and More →Why Omega-3s are important for ApoE4s: added paper: Circulating Docosahexaenoic Acid and Risk of All-Cause and Cause-Specific Mortality (Evan L. O’Keefe et al, 20 Mar 2024) current
- 08:38, 29 March 2024 diff hist +1,513 Cannabinoids: CBD, CBN, THC. Also HEMP & Marijuana (Cannabis) →Bioavailability: added paper on vaping health concerns: Evidence That Metal Particles in Cannabis Vape Liquids Limit Measurement Reproducibility'''](Zuzana Gajdosechova et al, 14 Nov 2022 current
- 09:16, 28 March 2024 diff hist +490 ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Greater incidence of postoperative delirium: added Apolipoprotein E e4 allele does not increase the risk of early postoperative delirium after major surgery (Fernando José Abelha et al, 1 Feb 2012) current
- 09:05, 28 March 2024 diff hist +614 Main Page elaborated on subjects discussed in Other Conditions besides (or maybe contributing to) Alzheimer's current
- 08:55, 28 March 2024 diff hist +4,766 ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Post Operative Cognitive Decline (POCD) after General Anesthesia: added discussion and papers
- 08:31, 28 March 2024 diff hist +1,108 ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s Started new subheading discussion: Post-Operative Cognitive Decline (POCD) after General Anesthesia
- 18:31, 27 March 2024 diff hist +692 ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Greater incidence of postoperative delirium: added paper Apolipoprotein-E-e4-Allele-Increases-the-Risk-of Apolipoprotein E e4 Allele Increases the Risk of Early Postoperative Delirium in Older Patients Undergoing Noncardiac Surgery (Jacqueline M. Leung et al, Sep 2007)
- 18:28, 27 March 2024 diff hist +523 ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Greater incidence of postoperative delirium: added explanation of delirium
- 17:08, 27 March 2024 diff hist +1,818 Beneficial (and some negative) Plant/Natural Chemicals →Fungi (mushrooms): added discussion of bioactive compounds in mushrooms current
- 13:19, 23 March 2024 diff hist +794 Beneficial (and some negative) Plant/Natural Chemicals →Terms K - O: added Oxyimperatorin (OIMP) to terms
- 12:56, 23 March 2024 diff hist +1,850 ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s added subheading: Greater incidence of postoperative delirium, and paper" Apolipoprotein E Genotype and the Association between C-reactive Protein and Postoperative Delirium: Importance of Gene-Protein Interactions (Sarinnapha M. Vasunilashorn et al, 1 Mar 2021),
- 07:37, 21 March 2024 diff hist +1,300 Ketosis and Ketogenic Diet →Additional references on ketosis or the introduction of ketones on cognition /Alzheimer’s: added paper: Ketogenic diet and BHB rescue the fall of long-term potentiation in an Alzheimer’s mouse model and stimulates synaptic plasticity pathway enzymes (Jacopo Di Lucente et al, 16 Feb 2024) current
- 14:29, 19 March 2024 diff hist +1,700 Fats, Omega -3(ω-3) & -6(ω-6), DHA and More →A deeper dive into the science on Omega-3s: added paper: ''Baseline Findings of PreventE4: A Double-Blind Placebo Controlled Clinical Trial Testing High Dose DHA in APOE4 Carriers before the Onset of Dementia (Hussein Yassine et al, 19 June 2023) and reordered papers
- 13:57, 19 March 2024 diff hist +845 Insulin Resistance in the brain →A deeper dive into the science: added paper: State of the Science on Brain Insulin Resistance and Cognitive Decline Due to Alzheimer’s Disease' (Elizabeth M. Rhea et al, 2023)
- 08:15, 18 March 2024 diff hist +124 Optimize antioxidants added cross reference to ApoE4.info wiki article: Beneficial (and some negative) Plant/Natural Chemicals current
- 08:09, 18 March 2024 diff hist +84 Optimize mitochondrial function Added cross reference to ApoE4.info wiki article: Mitochondria current
- 08:06, 18 March 2024 diff hist +33 Exercise fixed crossreference from Stress to Exercise current
- 08:03, 18 March 2024 diff hist +135 GI health Added cross reference to ApoE4.info wiki: Gut-Brain Connection: Leaky Gut/Leaky Brain, Microbiome (gut bugs) current
- 08:00, 18 March 2024 diff hist +75 Exercise added cross reference to ApoE4.info wiki article: Stress
- 07:46, 18 March 2024 diff hist +74 Reduce stress added cross reference to ApoE4.info wiki Stress current
- 07:44, 18 March 2024 diff hist 0 m Reduce stress fixed typo
- 07:43, 18 March 2024 diff hist +12 m Optimize sleep bold font current
- 07:41, 18 March 2024 diff hist +206 Enhance autophagy, ketogenesis added cross reference to ApoE4.info wiki articles "Ketosis and Ketogebic Diet" and Coconut Oil, MCT Oil, and other Ketone/Ccgnition boosters current
- 07:35, 18 March 2024 diff hist +114 Optimize sleep added cross reference links to Sleep and Circadian Rhythm
- 07:44, 15 March 2024 diff hist −95 m Coffee (and caffeine) →Proposed mechanism(s): minor elimination current
- 07:42, 15 March 2024 diff hist +648 Coffee (and caffeine) →Proposed mechanism(s): added possible aluminum based neurotoxicity protection of caffeinated coffee and paper, Evaluating the Neuroprotective Potential of Caffeinated Coffee in the Context of Aluminum-Induced Neurotoxicity: Insights from a PC12 Cell Culture Model (Kamil Rodak et al, 13 Mar 2024)
- 09:02, 14 March 2024 diff hist +399 Main Page →Introduction to APOE4: added paper, Cognitively healthy APOE4/4 carriers show white matter impairment associated with serum NfL and amyloid-PET (Claudia Tato-Fernández et al, Mar 2024) which found early white matter impairment in APOE4/4 homozygotes.
- 08:45, 14 March 2024 diff hist +1,231 Beneficial (and some negative) Plant/Natural Chemicals →Terms P - T: in term Trigonelline removed bad link and updated with newer research paper and elaborated more on benefits
- 08:32, 14 March 2024 diff hist +1,725 Coffee (and caffeine) →Proposed mechanism(s): added about trigonelline an alkaloid found in coffee and coffee byproducts
- 12:44, 3 March 2024 diff hist +494 Beneficial (and some negative) Plant/Natural Chemicals →Terms P - T: added sulforaphane to terms
- 12:40, 3 March 2024 diff hist +219 ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Small Vessel Disease (SVD): added Dr Rhonda Patrick's article on Small Vessel Disease
- 15:05, 2 March 2024 diff hist +6 m Main Page →Introduction to APOE4: bold font
- 15:04, 2 March 2024 diff hist +210 Main Page →Introduction to APOE4: added source
- 15:00, 2 March 2024 diff hist +84 Main Page →Introduction to APOE4: added how FAD is different than LOAD at the cellular level
- 08:57, 2 March 2024 diff hist −30 Main Page →Introduction to APOE4: fixed caption
- 08:40, 2 March 2024 diff hist +749 Main Page →Introduction to APOE4: added subheadings to ease readability
- 16:11, 1 March 2024 diff hist +640 ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Decreased Longevity: added paper: Evaluation of genotype-specific survival using joint analysis of genetic and non-genetic subsamples of longitudinal data'''] (Konstantin G. Arbeev et al, Apr 2011)
- 16:08, 1 March 2024 diff hist +586 ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Decreased Longevity: added paper: Trade-off in the effects of the apolipoprotein E polymorphism on the ages at onset of CVD and cancer influences human lifespan (Alexander M. Kulminski et al, Jun 2011)
- 16:05, 1 March 2024 diff hist +707 ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Decreased Longevity: added paper: Effect of the APOE Polymorphism and Age Trajectories of Physiological Variables on Mortality: Application of Genetic Stochastic Process Model of Aging'''] (Konstantin G. Arbeev et al, 2 Jul 2012)
- 16:03, 1 March 2024 diff hist +797 ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Decreased Longevity: added paper: Age, Gender, and Cancer but Not Neurodegenerative and Cardiovascular Diseases Strongly Modulate Systemic Effect of the Apolipoprotein E4 Allele on Lifespan'''] (Alexander M. Kulminski et al, Jan 2014)
- 16:01, 1 March 2024 diff hist +702 ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Decreased Longevity: added paper: The ApoE gene is related with exceptional longevity: a systematic review and meta-analysis (Nuria Garatachean et al, Feb 2018)
- 15:58, 1 March 2024 diff hist +915 ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Decreased Longevity: added paper: APOE Alleles and Extreme Human Longevity (Paola Sebastiani et al, Jan 2019)
- 15:55, 1 March 2024 diff hist +686 ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Decreased Longevity: added paper: The Genetic Variability of APOE in Different Human Populations and Its Implications for Longevity'''] (Paolo Abondio et al, Mar 2019)
- 15:51, 1 March 2024 diff hist +589 ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Decreased Longevity: added paper:Varying Effects of APOE Alleles on Extreme Longevity in European Ethnicities (Anastasia Gurinovich et al, Nov 2019)
- 15:48, 1 March 2024 diff hist +706 ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Decreased Longevity: added paper: Understanding Alzheimer’s disease in the context of aging: Findings from applications of stochastic process models to the Health and Retirement Study (Konstantin G. Arbeev et al, Apr 2023)
- 15:44, 1 March 2024 diff hist +697 ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Decreased Longevity: added paper: How are APOE4, changes in body weight, and longevity related? Insights from a causal mediation analysis'''] (Rachel Holmes et al, 1 Mar 2024)
- 08:28, 27 February 2024 diff hist +879 Beneficial (and some negative) Plant/Natural Chemicals →Terms A - E: added caffeic-acid
- 14:34, 26 February 2024 diff hist +498 Exercise - Types, Lengths, and Benefits →Exercise and the Brain: added paper: Exercise restores brain insulin sensitivity in sedentary adults who are overweight and obese (Stephanie Kullmann 22 Sep 2022) current
- 14:27, 26 February 2024 diff hist +1,111 Gut-Brain Connection: Leaky Gut/Leaky Brain, Microbiome (gut bugs) →Alzheimer’s Disease and gut health: added paper: Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases'''](Jian Sheng Loh et al, 2/16/2024) current
- 14:22, 26 February 2024 diff hist +331 Beneficial (and some negative) Plant/Natural Chemicals →Terms F - J: Under Ginger added paper: Screening of Active Substances Regulating Alzheimer’s Disease in Ginger and Visualization of the Effectiveness on 6-Gingerol Pathway Targets
- 18:11, 25 February 2024 diff hist −22 Main Page →Introduction to APOE4: fixed author's name on paper
- 12:22, 11 February 2024 diff hist −1 m Exercise - Types, Lengths, and Benefits →Vibration plate therapy: removed unneeded quotation mark
- 12:11, 11 February 2024 diff hist +635 Exercise - Types, Lengths, and Benefits →Vibration plate therapy: added rat study that found vibration aided anxiety, cognitive and motor decline, and neuroinflammation
- 08:29, 11 February 2024 diff hist +84 Main Page →Introduction to APOE4: added " oversees the releasing and transporting of lipids between cell types in the brain"
- 18:43, 10 February 2024 diff hist +11 m Main Page →Introduction to APOE4: superscript to footnotes
- 16:01, 10 February 2024 diff hist 0 m Main Page →Introduction to APOE4: fixed misspelling
- 15:53, 10 February 2024 diff hist +1 m Main Page →Introduction to APOE4: added needed space
- 15:52, 10 February 2024 diff hist −5 m Main Page →Introduction to APOE4: minor wordsmith
- 15:48, 10 February 2024 diff hist +55 m Main Page →Introduction to APOE4: grammatical & other minor fixes
- 15:40, 10 February 2024 diff hist +1 m Main Page →Introduction to APOE4: added comma
- 15:39, 10 February 2024 diff hist −4 m Main Page →Introduction to APOE4: took out awkward word
- 14:51, 10 February 2024 diff hist +113 m Main Page →Introduction to APOE4: added that most doctors not trained in diet and lifestyle interventions.
- 14:48, 10 February 2024 diff hist +1 m Main Page →Introduction to APOE4: fixed word
- 14:46, 10 February 2024 diff hist +4 m Main Page →Introduction to APOE4: fixed term
- 13:16, 10 February 2024 diff hist +1,696 Main Page →Introduction to APOE4: added about precision medicine being the future
- 12:52, 10 February 2024 diff hist +156 m Main Page →Introduction to APOE4: more re-adds
- 12:39, 10 February 2024 diff hist +1 m Main Page →Introduction to APOE4: fixed link
- 12:38, 10 February 2024 diff hist +29 m Main Page →Introduction to APOE4: repositioned paragraph
- 12:34, 10 February 2024 diff hist +32 m Main Page →Introduction to APOE4: re-add
- 11:16, 10 February 2024 diff hist +21 m Main Page →Introduction to APOE4
- 11:14, 10 February 2024 diff hist +22 m Main Page →Introduction to APOE4: link
- 11:13, 10 February 2024 diff hist +88 m Main Page →Introduction to APOE4: added link
- 11:05, 10 February 2024 diff hist +1 m Main Page →Introduction to APOE4
- 10:59, 10 February 2024 diff hist +6 m Main Page →Introduction to APOE4: bold font
- 10:58, 10 February 2024 diff hist −1 m Main Page →Introduction to APOE4: typo
- 10:57, 10 February 2024 diff hist +49 m Main Page →Introduction to APOE4
- 10:55, 10 February 2024 diff hist +10 Main Page →Introduction to APOE4: fixed graphics
- 10:42, 10 February 2024 diff hist +1,969 Main Page →Introduction to APOE4: many re-adds
- 10:25, 10 February 2024 diff hist +10 m Main Page →Introduction to APOE4: minor
- 10:25, 10 February 2024 diff hist −13 Main Page →Introduction to APOE4: minor
- 10:23, 10 February 2024 diff hist +104 Main Page →Introduction to APOE4: influence of factors on ailments of age
- 10:20, 10 February 2024 diff hist +623 Main Page →Introduction to APOE4: re added bottom line
- 10:17, 10 February 2024 diff hist +48 Main Page →Introduction to APOE4: minor
- 10:15, 10 February 2024 diff hist +1 Main Page →Introduction to APOE4: added space
- 10:14, 10 February 2024 diff hist +53 Main Page →Introduction to APOE4: global variation
- 10:13, 10 February 2024 diff hist +1 Main Page →Introduction to APOE4: fixed caption
- 10:06, 10 February 2024 diff hist 0 Main Page →Introduction to APOE4
- 10:04, 10 February 2024 diff hist +951 Main Page →Introduction to APOE4: added on organ aging
- 10:01, 10 February 2024 diff hist +899 Main Page →Introduction to APOE4: added odds of AD
- 09:58, 10 February 2024 diff hist +752 Main Page →Introduction to APOE4: apoe4 nickname
- 09:51, 10 February 2024 diff hist +203 Main Page →Introduction to APOE4: returned revised intro
- 09:48, 10 February 2024 diff hist +1,441 Main Page →Introduction to APOE4: re-added graphic of APOE4 brain vs non 4 brain w discussion
- 09:39, 10 February 2024 diff hist +1,411 Main Page →Introduction to APOE4: returned discussion on sporadic AD & not the only genetic factor
- 09:33, 10 February 2024 diff hist −453 Main Page →Introduction to APOE4: LOAD vs EOAD
- 09:30, 10 February 2024 diff hist +1,538 Main Page →Introduction to APOE4: returned discussion on being maladjusted to modern times
- 09:26, 10 February 2024 diff hist +58 Main Page →Introduction to APOE4: graphic
- 09:23, 10 February 2024 diff hist −3 Main Page →Introduction to APOE4: graphic
- 09:16, 10 February 2024 diff hist +9 m Main Page →Introduction: title