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- 09:16, 28 March 2024 diff hist +490 ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Greater incidence of postoperative delirium: added Apolipoprotein E e4 allele does not increase the risk of early postoperative delirium after major surgery (Fernando José Abelha et al, 1 Feb 2012) current
- 09:05, 28 March 2024 diff hist +614 Main Page elaborated on subjects discussed in Other Conditions besides (or maybe contributing to) Alzheimer's current
- 08:55, 28 March 2024 diff hist +4,766 ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Post Operative Cognitive Decline (POCD) after General Anesthesia: added discussion and papers
- 08:31, 28 March 2024 diff hist +1,108 ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s Started new subheading discussion: Post-Operative Cognitive Decline (POCD) after General Anesthesia
- 18:31, 27 March 2024 diff hist +692 ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Greater incidence of postoperative delirium: added paper Apolipoprotein-E-e4-Allele-Increases-the-Risk-of Apolipoprotein E e4 Allele Increases the Risk of Early Postoperative Delirium in Older Patients Undergoing Noncardiac Surgery (Jacqueline M. Leung et al, Sep 2007)
- 18:28, 27 March 2024 diff hist +523 ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Greater incidence of postoperative delirium: added explanation of delirium
- 17:08, 27 March 2024 diff hist +1,818 Beneficial (and some negative) Plant/Natural Chemicals →Fungi (mushrooms): added discussion of bioactive compounds in mushrooms current
- 13:19, 23 March 2024 diff hist +794 Beneficial (and some negative) Plant/Natural Chemicals →Terms K - O: added Oxyimperatorin (OIMP) to terms
- 12:56, 23 March 2024 diff hist +1,850 ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s added subheading: Greater incidence of postoperative delirium, and paper" Apolipoprotein E Genotype and the Association between C-reactive Protein and Postoperative Delirium: Importance of Gene-Protein Interactions (Sarinnapha M. Vasunilashorn et al, 1 Mar 2021),
- 07:37, 21 March 2024 diff hist +1,300 Ketosis and Ketogenic Diet →Additional references on ketosis or the introduction of ketones on cognition /Alzheimer’s: added paper: Ketogenic diet and BHB rescue the fall of long-term potentiation in an Alzheimer’s mouse model and stimulates synaptic plasticity pathway enzymes (Jacopo Di Lucente et al, 16 Feb 2024) current
- 14:29, 19 March 2024 diff hist +1,700 Fats, Omega -3(ω-3) & -6(ω-6), DHA and More →A deeper dive into the science on Omega-3s: added paper: ''Baseline Findings of PreventE4: A Double-Blind Placebo Controlled Clinical Trial Testing High Dose DHA in APOE4 Carriers before the Onset of Dementia (Hussein Yassine et al, 19 June 2023) and reordered papers current
- 13:57, 19 March 2024 diff hist +845 Insulin Resistance in the brain →A deeper dive into the science: added paper: State of the Science on Brain Insulin Resistance and Cognitive Decline Due to Alzheimer’s Disease' (Elizabeth M. Rhea et al, 2023) current
- 08:15, 18 March 2024 diff hist +124 Optimize antioxidants added cross reference to ApoE4.info wiki article: Beneficial (and some negative) Plant/Natural Chemicals current
- 08:09, 18 March 2024 diff hist +84 Optimize mitochondrial function Added cross reference to ApoE4.info wiki article: Mitochondria current
- 08:06, 18 March 2024 diff hist +33 Exercise fixed crossreference from Stress to Exercise current
- 08:03, 18 March 2024 diff hist +135 GI health Added cross reference to ApoE4.info wiki: Gut-Brain Connection: Leaky Gut/Leaky Brain, Microbiome (gut bugs) current
- 08:00, 18 March 2024 diff hist +75 Exercise added cross reference to ApoE4.info wiki article: Stress
- 07:46, 18 March 2024 diff hist +74 Reduce stress added cross reference to ApoE4.info wiki Stress current
- 07:44, 18 March 2024 diff hist 0 m Reduce stress fixed typo
- 07:43, 18 March 2024 diff hist +12 m Optimize sleep bold font current
- 07:41, 18 March 2024 diff hist +206 Enhance autophagy, ketogenesis added cross reference to ApoE4.info wiki articles "Ketosis and Ketogebic Diet" and Coconut Oil, MCT Oil, and other Ketone/Ccgnition boosters current
- 07:35, 18 March 2024 diff hist +114 Optimize sleep added cross reference links to Sleep and Circadian Rhythm
- 07:44, 15 March 2024 diff hist −95 m Coffee (and caffeine) →Proposed mechanism(s): minor elimination current
- 07:42, 15 March 2024 diff hist +648 Coffee (and caffeine) →Proposed mechanism(s): added possible aluminum based neurotoxicity protection of caffeinated coffee and paper, Evaluating the Neuroprotective Potential of Caffeinated Coffee in the Context of Aluminum-Induced Neurotoxicity: Insights from a PC12 Cell Culture Model (Kamil Rodak et al, 13 Mar 2024)
- 09:02, 14 March 2024 diff hist +399 Main Page →Introduction to APOE4: added paper, Cognitively healthy APOE4/4 carriers show white matter impairment associated with serum NfL and amyloid-PET (Claudia Tato-Fernández et al, Mar 2024) which found early white matter impairment in APOE4/4 homozygotes.
- 08:45, 14 March 2024 diff hist +1,231 Beneficial (and some negative) Plant/Natural Chemicals →Terms P - T: in term Trigonelline removed bad link and updated with newer research paper and elaborated more on benefits
- 08:32, 14 March 2024 diff hist +1,725 Coffee (and caffeine) →Proposed mechanism(s): added about trigonelline an alkaloid found in coffee and coffee byproducts
- 12:44, 3 March 2024 diff hist +494 Beneficial (and some negative) Plant/Natural Chemicals →Terms P - T: added sulforaphane to terms
- 12:40, 3 March 2024 diff hist +219 ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Small Vessel Disease (SVD): added Dr Rhonda Patrick's article on Small Vessel Disease
- 15:05, 2 March 2024 diff hist +6 m Main Page →Introduction to APOE4: bold font
- 15:04, 2 March 2024 diff hist +210 Main Page →Introduction to APOE4: added source
- 15:00, 2 March 2024 diff hist +84 Main Page →Introduction to APOE4: added how FAD is different than LOAD at the cellular level
- 08:57, 2 March 2024 diff hist −30 Main Page →Introduction to APOE4: fixed caption
- 08:40, 2 March 2024 diff hist +749 Main Page →Introduction to APOE4: added subheadings to ease readability
- 16:11, 1 March 2024 diff hist +640 ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Decreased Longevity: added paper: Evaluation of genotype-specific survival using joint analysis of genetic and non-genetic subsamples of longitudinal data'''] (Konstantin G. Arbeev et al, Apr 2011)
- 16:08, 1 March 2024 diff hist +586 ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Decreased Longevity: added paper: Trade-off in the effects of the apolipoprotein E polymorphism on the ages at onset of CVD and cancer influences human lifespan (Alexander M. Kulminski et al, Jun 2011)
- 16:05, 1 March 2024 diff hist +707 ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Decreased Longevity: added paper: Effect of the APOE Polymorphism and Age Trajectories of Physiological Variables on Mortality: Application of Genetic Stochastic Process Model of Aging'''] (Konstantin G. Arbeev et al, 2 Jul 2012)
- 16:03, 1 March 2024 diff hist +797 ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Decreased Longevity: added paper: Age, Gender, and Cancer but Not Neurodegenerative and Cardiovascular Diseases Strongly Modulate Systemic Effect of the Apolipoprotein E4 Allele on Lifespan'''] (Alexander M. Kulminski et al, Jan 2014)
- 16:01, 1 March 2024 diff hist +702 ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Decreased Longevity: added paper: The ApoE gene is related with exceptional longevity: a systematic review and meta-analysis (Nuria Garatachean et al, Feb 2018)
- 15:58, 1 March 2024 diff hist +915 ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Decreased Longevity: added paper: APOE Alleles and Extreme Human Longevity (Paola Sebastiani et al, Jan 2019)
- 15:55, 1 March 2024 diff hist +686 ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Decreased Longevity: added paper: The Genetic Variability of APOE in Different Human Populations and Its Implications for Longevity'''] (Paolo Abondio et al, Mar 2019)
- 15:51, 1 March 2024 diff hist +589 ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Decreased Longevity: added paper:Varying Effects of APOE Alleles on Extreme Longevity in European Ethnicities (Anastasia Gurinovich et al, Nov 2019)
- 15:48, 1 March 2024 diff hist +706 ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Decreased Longevity: added paper: Understanding Alzheimer’s disease in the context of aging: Findings from applications of stochastic process models to the Health and Retirement Study (Konstantin G. Arbeev et al, Apr 2023)
- 15:44, 1 March 2024 diff hist +697 ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Decreased Longevity: added paper: How are APOE4, changes in body weight, and longevity related? Insights from a causal mediation analysis'''] (Rachel Holmes et al, 1 Mar 2024)
- 08:28, 27 February 2024 diff hist +879 Beneficial (and some negative) Plant/Natural Chemicals →Terms A - E: added caffeic-acid
- 14:34, 26 February 2024 diff hist +498 Exercise - Types, Lengths, and Benefits →Exercise and the Brain: added paper: Exercise restores brain insulin sensitivity in sedentary adults who are overweight and obese (Stephanie Kullmann 22 Sep 2022) current
- 14:27, 26 February 2024 diff hist +1,111 Gut-Brain Connection: Leaky Gut/Leaky Brain, Microbiome (gut bugs) →Alzheimer’s Disease and gut health: added paper: Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases'''](Jian Sheng Loh et al, 2/16/2024) current
- 14:22, 26 February 2024 diff hist +331 Beneficial (and some negative) Plant/Natural Chemicals →Terms F - J: Under Ginger added paper: Screening of Active Substances Regulating Alzheimer’s Disease in Ginger and Visualization of the Effectiveness on 6-Gingerol Pathway Targets
- 18:11, 25 February 2024 diff hist −22 Main Page →Introduction to APOE4: fixed author's name on paper
- 12:22, 11 February 2024 diff hist −1 m Exercise - Types, Lengths, and Benefits →Vibration plate therapy: removed unneeded quotation mark
- 12:11, 11 February 2024 diff hist +635 Exercise - Types, Lengths, and Benefits →Vibration plate therapy: added rat study that found vibration aided anxiety, cognitive and motor decline, and neuroinflammation
- 08:29, 11 February 2024 diff hist +84 Main Page →Introduction to APOE4: added " oversees the releasing and transporting of lipids between cell types in the brain"
- 18:43, 10 February 2024 diff hist +11 m Main Page →Introduction to APOE4: superscript to footnotes
- 16:01, 10 February 2024 diff hist 0 m Main Page →Introduction to APOE4: fixed misspelling
- 15:53, 10 February 2024 diff hist +1 m Main Page →Introduction to APOE4: added needed space
- 15:52, 10 February 2024 diff hist −5 m Main Page →Introduction to APOE4: minor wordsmith
- 15:48, 10 February 2024 diff hist +55 m Main Page →Introduction to APOE4: grammatical & other minor fixes
- 15:40, 10 February 2024 diff hist +1 m Main Page →Introduction to APOE4: added comma
- 15:39, 10 February 2024 diff hist −4 m Main Page →Introduction to APOE4: took out awkward word
- 14:51, 10 February 2024 diff hist +113 m Main Page →Introduction to APOE4: added that most doctors not trained in diet and lifestyle interventions.
- 14:48, 10 February 2024 diff hist +1 m Main Page →Introduction to APOE4: fixed word
- 14:46, 10 February 2024 diff hist +4 m Main Page →Introduction to APOE4: fixed term
- 13:16, 10 February 2024 diff hist +1,696 Main Page →Introduction to APOE4: added about precision medicine being the future
- 12:52, 10 February 2024 diff hist +156 m Main Page →Introduction to APOE4: more re-adds
- 12:39, 10 February 2024 diff hist +1 m Main Page →Introduction to APOE4: fixed link
- 12:38, 10 February 2024 diff hist +29 m Main Page →Introduction to APOE4: repositioned paragraph
- 12:34, 10 February 2024 diff hist +32 m Main Page →Introduction to APOE4: re-add
- 11:16, 10 February 2024 diff hist +21 m Main Page →Introduction to APOE4
- 11:14, 10 February 2024 diff hist +22 m Main Page →Introduction to APOE4: link
- 11:13, 10 February 2024 diff hist +88 m Main Page →Introduction to APOE4: added link
- 11:05, 10 February 2024 diff hist +1 m Main Page →Introduction to APOE4
- 10:59, 10 February 2024 diff hist +6 m Main Page →Introduction to APOE4: bold font
- 10:58, 10 February 2024 diff hist −1 m Main Page →Introduction to APOE4: typo
- 10:57, 10 February 2024 diff hist +49 m Main Page →Introduction to APOE4
- 10:55, 10 February 2024 diff hist +10 Main Page →Introduction to APOE4: fixed graphics
- 10:42, 10 February 2024 diff hist +1,969 Main Page →Introduction to APOE4: many re-adds
- 10:25, 10 February 2024 diff hist +10 m Main Page →Introduction to APOE4: minor
- 10:25, 10 February 2024 diff hist −13 Main Page →Introduction to APOE4: minor
- 10:23, 10 February 2024 diff hist +104 Main Page →Introduction to APOE4: influence of factors on ailments of age
- 10:20, 10 February 2024 diff hist +623 Main Page →Introduction to APOE4: re added bottom line
- 10:17, 10 February 2024 diff hist +48 Main Page →Introduction to APOE4: minor
- 10:15, 10 February 2024 diff hist +1 Main Page →Introduction to APOE4: added space
- 10:14, 10 February 2024 diff hist +53 Main Page →Introduction to APOE4: global variation
- 10:13, 10 February 2024 diff hist +1 Main Page →Introduction to APOE4: fixed caption
- 10:06, 10 February 2024 diff hist 0 Main Page →Introduction to APOE4
- 10:04, 10 February 2024 diff hist +951 Main Page →Introduction to APOE4: added on organ aging
- 10:01, 10 February 2024 diff hist +899 Main Page →Introduction to APOE4: added odds of AD
- 09:58, 10 February 2024 diff hist +752 Main Page →Introduction to APOE4: apoe4 nickname
- 09:51, 10 February 2024 diff hist +203 Main Page →Introduction to APOE4: returned revised intro
- 09:48, 10 February 2024 diff hist +1,441 Main Page →Introduction to APOE4: re-added graphic of APOE4 brain vs non 4 brain w discussion
- 09:39, 10 February 2024 diff hist +1,411 Main Page →Introduction to APOE4: returned discussion on sporadic AD & not the only genetic factor
- 09:33, 10 February 2024 diff hist −453 Main Page →Introduction to APOE4: LOAD vs EOAD
- 09:30, 10 February 2024 diff hist +1,538 Main Page →Introduction to APOE4: returned discussion on being maladjusted to modern times
- 09:26, 10 February 2024 diff hist +58 Main Page →Introduction to APOE4: graphic
- 09:23, 10 February 2024 diff hist −3 Main Page →Introduction to APOE4: graphic
- 09:16, 10 February 2024 diff hist +9 m Main Page →Introduction: title
- 08:56, 10 February 2024 diff hist −9,611 m Main Page Reverted edits by Theresab (talk) to last revision by Nf52 Tag: Rollback
- 08:55, 10 February 2024 diff hist +1 m Main Page →Introduction to APOE4: fixed grammar
- 08:35, 4 February 2024 diff hist 0 N File:Hyman on gene regulation.jpg current
- 12:44, 3 February 2024 diff hist −7 m Main Page removed redundancy
- 12:42, 3 February 2024 diff hist −14 m Main Page minor wordsmith
- 12:40, 3 February 2024 diff hist +46 m Main Page added other alleles can also get LOAD
- 12:38, 3 February 2024 diff hist −2 m Main Page minor fix
- 12:36, 3 February 2024 diff hist +7 m Main Page minor wordsmith
- 12:35, 3 February 2024 diff hist 0 m Main Page minor fix
- 12:34, 3 February 2024 diff hist +1 m Main Page closed parentheses
- 12:32, 3 February 2024 diff hist +1 m Main Page added a comma
- 12:31, 3 February 2024 diff hist −50 m Main Page shortened sentence eliminating unnecessary info
- 12:27, 3 February 2024 diff hist −1 m Main Page minor wordsmith
- 11:48, 3 February 2024 diff hist −2 m Main Page →Introduction to APOE4: minor fix
- 10:35, 3 February 2024 diff hist +4 m Main Page →Introduction to APOE4: added a needed "the"
- 10:06, 3 February 2024 diff hist +473 Main Page →Introduction to APOE4: added papert Could Alzheimer’s disease be a maladaptation of an evolutionary survival pathway mediated by intracerebral fructose and uric acid metabolism?' (Richard J. Johnson et al, Mar 2023)
- 09:57, 3 February 2024 diff hist +91 m Main Page →Introduction to APOE4: minor
- 09:54, 3 February 2024 diff hist +644 Main Page →Introduction to APOE4: added paper 'Dementia in the Ancient Greco-Roman World Was Minimally Mentioned'''](Caleb E Finch et al, 25 Jan 2024)
- 14:59, 1 February 2024 diff hist +20 m Main Page →Introduction to APOE4: minor wordsmith
- 07:21, 1 February 2024 diff hist +19 m Main Page more exact wording
- 21:23, 31 January 2024 diff hist +198 Main Page wordsmithed caption
- 21:06, 31 January 2024 diff hist +37 Main Page Added success quote
- 21:00, 31 January 2024 diff hist 0 N File:23 12 19 Success.jpg current
- 21:00, 31 January 2024 diff hist +322 Main Page added Permutter quote
- 20:55, 31 January 2024 diff hist 0 N File:24 01 08 Perlmutter on diet trumps genes.jpg current
- 20:50, 31 January 2024 diff hist +5 m Main Page wordsmith
- 20:49, 31 January 2024 diff hist −444 m Main Page wordsmithed caption for greater clarity
- 20:44, 31 January 2024 diff hist +120 Main Page added quote from Dr Bredesen
- 20:40, 31 January 2024 diff hist +36 N File:23 08 21 Bredesen quote on Alzheimer's.jpg Quote from Dr Bredesen current
- 17:09, 31 January 2024 diff hist +624 Sleep →A deeper dive into the science: added paper Suboptimal Sleep Duration Is Associated With Poorer Neuroimaging Brain Health Profiles in Middle‐Aged Individuals Without Stroke or Dementia (Santiago Clocchiatti‐Tuozzo et al, 2 Jan 2024) current
- 08:45, 31 January 2024 diff hist +1,106 Mitochondria →Other research on mitochondria and Alzheimer’s Disease: added paper: Mitochondria in Alzheimer’s Disease Pathogenesis (Reiss, A.B et al, 30 Jan 2024) current
- 07:47, 31 January 2024 diff hist +10 m Main Page minor wordsmith
- 20:37, 30 January 2024 diff hist −6 Main Page deleted word
- 20:35, 30 January 2024 diff hist +1,096 Main Page added study on organ aging: Organ aging signatures in the plasma proteome track health and disease (Hamilton Se-Hwee Oh, et al, 6 Dec 2023):
- 15:08, 28 January 2024 diff hist −9 m Main Page fix
- 15:07, 28 January 2024 diff hist −2 m Main Page typo
- 15:06, 28 January 2024 diff hist −2 m Main Page typo
- 12:30, 28 January 2024 diff hist +8 m Main Page minor wordsmithing
- 12:28, 28 January 2024 diff hist −107 m Main Page minor wordsmithing
- 12:23, 28 January 2024 diff hist −37 m Main Page minor wordsmithing
- 12:21, 28 January 2024 diff hist 0 Main Page that comma I just added, it was actually an "m", it is now a comma
- 12:20, 28 January 2024 diff hist +1 m Main Page added a comma
- 12:18, 28 January 2024 diff hist +53 m Main Page minor wordsmithing
- 12:16, 28 January 2024 diff hist +23 m Main Page minor fixes
- 12:07, 28 January 2024 diff hist +910 Main Page added paragraph addressing odds of getting AD
- 11:55, 28 January 2024 diff hist +1,169 Main Page discussed how "Alzheimer's Gene" is a poor nickname
- 10:14, 27 January 2024 diff hist +586 Main Page added bottom line, e4 not deterministic, extra important for us to follow lifestyle choices
- 09:25, 27 January 2024 diff hist +79 Main Page added that e4s get LOAD earlier in life
- 09:19, 27 January 2024 diff hist +136 Main Page added EOAD/FAD only truly genetically driven AD
- 09:04, 27 January 2024 diff hist +6 m Main Page added ε
- 08:59, 27 January 2024 diff hist +1 m Main Page added a comma
- 08:58, 27 January 2024 diff hist +9 m Main Page minor wordsmithing
- 08:56, 27 January 2024 diff hist +78 m Main Page added that e4 is also associated with other forms of dementia
- 08:52, 27 January 2024 diff hist −17 m Main Page replaced gene with allele
- 08:50, 27 January 2024 diff hist 0 m Main Page minor fix
- 08:47, 27 January 2024 diff hist +23 m Main Page →Introduction to APOE4: bolded protein - isoform, gene - alleles
- 08:46, 27 January 2024 diff hist −1 m Main Page typo fix
- 08:45, 27 January 2024 diff hist +1 m Main Page minor fix
- 08:43, 27 January 2024 diff hist +173 Main Page elaborated on the function of ApoE as a protein
- 08:20, 27 January 2024 diff hist +92 m Main Page added that Alzheimer's is considered one disease under broader dementia term
- 08:11, 27 January 2024 diff hist +1 m Main Page space added between comma & letter
- 08:09, 27 January 2024 diff hist +17 m Main Page minor wordsmithing
- 14:53, 26 January 2024 diff hist −1 m Main Page took source out of quote
- 14:49, 26 January 2024 diff hist 0 m Main Page closed parenthesis
- 14:48, 26 January 2024 diff hist +2 m Main Page fixed link
- 14:47, 26 January 2024 diff hist +109 m Main Page word smithed caption
- 14:44, 26 January 2024 diff hist 0 m Main Page fixed parenthesis
- 14:43, 26 January 2024 diff hist +11 m Main Page superscript
- 14:41, 26 January 2024 diff hist −1 m Main Page typo
- 14:40, 26 January 2024 diff hist 0 m Main Page fixed parenthesis
- 13:21, 26 January 2024 diff hist +1,014 Exercise - Types, Lengths, and Benefits →Exercise and ApoE4: added paper: "Exercise as Potential Therapeutic Target to Modulate Alzheimer’s Disease Pathology in APOE ε4 Carriers: A Systematic Review'"(Sevilay Tokgöz and Jurgen A. H. R. Claassen 5 Jan 2021)
- 12:25, 26 January 2024 diff hist +64 Main Page Added that EOAD is also known as Familial Alzheimer's Disease (FAD)
- 11:54, 26 January 2024 diff hist +23 m Main Page minor word smithing
- 11:40, 26 January 2024 diff hist +424 ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Cardiovascular Disease (CVD): added paper: Apolipoprotein E-ε2 and Resistance to Atherosclerosis in Midlife—The PESA Observational Study'''] (Raquel Toribio-Fernández et al, 23 Jan 2024)
- 11:24, 26 January 2024 diff hist −564 m Main Page abbreviated quote
- 11:21, 26 January 2024 diff hist 0 m Main Page fixed bolding in caption comparing brains of ApoE4s vs non 4s
- 11:19, 26 January 2024 diff hist +6 m Main Page bolded also called Sporadic Alzheimer's
- 11:18, 26 January 2024 diff hist +6 m Main Page bolded Late Onset Alzheimer's Disease
- 11:17, 26 January 2024 diff hist +798 Main Page added Alzheimer's doesn't appear to be one disease and paper: Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct genetic risk profiles (Betty M. Tijms et al,9 Jan 2024)
- 11:03, 26 January 2024 diff hist +882 Main Page added ApoE4 is not singular AD risk & quote from "Alzheimer’s disease risk reduction in clinical practice: a priority in the emerging field of preventive neurology" (Kellyann Niotis et al, 10 Jan 2024)
- 10:11, 26 January 2024 diff hist 0 m Main Page fixed typo
- 10:10, 26 January 2024 diff hist +1,296 Main Page added APOE4 alzheimer's is different and graphic from "APOE4 is associated with cognitive and pathological heterogeneity in patients with Alzheimer’s disease: a systematic review" (Sheina Emrani et al, 4 Nov 2020)
- 10:03, 26 January 2024 diff hist +259 N File:APOE4 AD heterogenity.jpg Figure 1 from "APOE4 is associated with cognitive and pathological heterogeneity in patients with Alzheimer’s disease: a systematic review" (Sheina Emrani et al, 4 Nov 2020) https://alzres.biomedcentral.com/articles/10.1186/s13195-020-00712-4 current
- 09:37, 26 January 2024 diff hist +811 ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s added subheading Greater susceptibility to pesticides and paper: Elevated Serum Pesticide Levels and Risk for Alzheimer Disease (Jason R. Richardson et al, Mar 2014)
- 20:24, 25 January 2024 diff hist +837 Gut-Brain Connection: Leaky Gut/Leaky Brain, Microbiome (gut bugs) →Alzheimer’s Disease and gut health: under deeper dive added: Current understanding of the Alzheimer’s disease-associated microbiome and therapeutic strategies (Dong-oh Seo & David M. Holtzman, 4 Jan 2024)
- 20:04, 25 January 2024 diff hist +380 ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Saturated Fat Sensitivity: added paper that found found high saturated fat diets are associated with a greater risk (7-fold increase) of Alzheimer’s disease for e4 carriers than non-e4 carriers in a northern European population.
- 09:35, 25 January 2024 diff hist +378 Non-white or non-European descent →Black/African descent: added paper: The Relationship of APOE ε4, Race, and Sex on the Age of Onset and Risk of Dementia (Danielle S. Powell et al, 20 Oct 2021) which found lower cerebrospinal fluid concentrations of tau biomarkers in Black APOE ε4 carriers current
- 09:03, 25 January 2024 diff hist +11 m Main Page →Introduction: tidied up new paragraph
- 09:01, 25 January 2024 diff hist −3 m Main Page →Introduction: fixed graphic placement that went wonky
- 08:58, 25 January 2024 diff hist −5 m Main Page →Introduction: fixed graphic placement that went wonky
- 08:56, 25 January 2024 diff hist +13 m Main Page →Introduction: fixed placement of graphic that went wonky
- 08:51, 25 January 2024 diff hist +1,202 Main Page →Introduction: added how treatment for APOE4s should be different than other genotypes with reference "Alzheimer’s disease risk reduction in clinical practice: a priority in the emerging field of preventive neurology"(Niotis et al, 1 Jan 2024))
- 21:24, 25 December 2023 diff hist +194 Exercise - Types, Lengths, and Benefits →Blood Flow Restriction (BFR) Bands (KAATSU, B Strong, etc.): Added STEM Talk on BFR
- 09:03, 22 December 2023 diff hist +527 Beneficial (and some negative) Plant/Natural Chemicals →Deeper dive into the science of natural products and health effects: added paper Flavonoids and fibrate modulate apoE4-induced processing of amyloid precursor protein in neuroblastoma cells (Viralkumar Davra and Kenza E. Benzeroual, 22 Dec 2023)
- 08:25, 22 December 2023 diff hist +614 Beneficial (and some negative) Plant/Natural Chemicals →Deeper dive into the science of natural products and health effects: added paper Effect of cocoa extract supplementation on cognitive function: results from the clinic subcohort of the COSMOS trial'''] (Chirag M Vyas et al, 7 Dec 2023)
- 11:33, 15 December 2023 diff hist −1 m Beneficial (and some negative) Plant/Natural Chemicals →Terms K - O: removed spaced
- 11:33, 15 December 2023 diff hist +558 Beneficial (and some negative) Plant/Natural Chemicals →Terms K - O: added L-theanine
- 21:28, 12 December 2023 diff hist +229 Beneficial (and some negative) Plant/Natural Chemicals →Terms A - E: added paper Cocoa Flavanols: Natural Agents with Attenuating Effects on Metabolic Syndrome Risk Factors (Maria Eugenia Jaramillo Flores, Apr 2019)
- 20:56, 12 December 2023 diff hist +335 Beneficial (and some negative) Plant/Natural Chemicals →Terms A - E: added paper: enefits in Cognitive Function, Blood Pressure, and Insulin Resistance Through Cocoa Flavanol Consumption in Elderly Subjects With Mild Cognitive Impairment
- 17:45, 12 December 2023 diff hist +491 Beneficial (and some negative) Plant/Natural Chemicals →Terms F - J: added term Gou-teng
- 17:40, 12 December 2023 diff hist +404 Beneficial (and some negative) Plant/Natural Chemicals →Terms F - J: added term Huperzine-A
- 17:34, 12 December 2023 diff hist +726 Beneficial (and some negative) Plant/Natural Chemicals →Terms A - E: added term cinnamic acid
- 17:19, 12 December 2023 diff hist +1,126 Beneficial (and some negative) Plant/Natural Chemicals →Terms A - E: added term cinnamon
- 17:01, 12 December 2023 diff hist +598 Beneficial (and some negative) Plant/Natural Chemicals →Terms F - J: added ginger w chinese cinnamon's synergistic effects
- 16:53, 12 December 2023 diff hist +416 Beneficial (and some negative) Plant/Natural Chemicals →Terms P - T: added term Rose
- 16:47, 12 December 2023 diff hist +999 Beneficial (and some negative) Plant/Natural Chemicals →Terms F - J: added term "Ginger"
- 16:41, 12 December 2023 diff hist +171 Beneficial (and some negative) Plant/Natural Chemicals →Introduction to plants and their chemicals: added quote from Dr Hyman on plants as medicine
- 16:39, 12 December 2023 diff hist +34 N File:Hyman quote on plants.jpg current
- 13:47, 8 December 2023 diff hist +1,158 Beneficial (and some negative) Plant/Natural Chemicals →Terms Starting Numerically: added 6-MSITC to terms
- 15:33, 6 December 2023 diff hist +75 N Cannabinoids, Cannabidiol (CBD), THC, HEMP, Marijuana, Cannabis Theresab moved page Cannabinoids, Cannabidiol (CBD), THC, HEMP, Marijuana, Cannabis to Cannabinoids: CBD, CBN, THC. Also HEMP & Marijuana (Cannabis): better title current Tag: New redirect
- 15:33, 6 December 2023 diff hist 0 m Cannabinoids: CBD, CBN, THC. Also HEMP & Marijuana (Cannabis) Theresab moved page Cannabinoids, Cannabidiol (CBD), THC, HEMP, Marijuana, Cannabis to Cannabinoids: CBD, CBN, THC. Also HEMP & Marijuana (Cannabis): better title current
- 14:20, 6 December 2023 diff hist −2 Main Page →Cannabinoids, Cannabidiol (CBD), THC, HEMP, Marijuana, Cannabis
- 12:31, 6 December 2023 diff hist +1,181 Beneficial (and some negative) Plant/Natural Chemicals →Terms F - J: added Fisetin
- 12:09, 6 December 2023 diff hist +1 m Mitochondria →Other research on mitochondria and Alzheimer’s Disease: added space
- 12:09, 6 December 2023 diff hist +6 m Mitochondria →Other research on mitochondria and Alzheimer’s Disease: bolded font
- 12:08, 6 December 2023 diff hist +733 Mitochondria →Other research on mitochondria and Alzheimer’s Disease: added paper: Decoding metabolic signatures in Alzheimer’s disease: a mitochondrial perspective (Daniele Bano et al, 1 Dec 2023)
- 13:30, 5 December 2023 diff hist 0 m Non-white or non-European descent →Hispanic, Latino, etc.: capitalized Hispanic
- 13:22, 5 December 2023 diff hist −2 m Non-white or non-European descent →Black/African descent: fixed stray letter additions (I blame the cat)
- 13:15, 5 December 2023 diff hist +1,118 Non-white or non-European descent →Hispanic, Latino, etc.: added paragraph on inconsistent results of ApoE4 in Hispanics, included references
- 13:04, 5 December 2023 diff hist +489 Non-white or non-European descent →Black/African descent: added paper: Association of Apolipoprotein E Genotype and Alzheimer Disease in African Americans'''] (Jill R. Murrell et al, Mar 2006)
- 11:45, 5 December 2023 diff hist +4 m Main Page →Fructose and Alzheimer's Disease: changed title to reflect article From Fructose to Alzheimer's
- 10:03, 5 December 2023 diff hist +1,035 Non-white or non-European descent →Hispanic, Latino, etc.: added intro citing that Hispanics have lower levels of Amyloid
- 09:38, 5 December 2023 diff hist +829 Non-white or non-European descent added article: Insight: Promising new Alzheimer's drugs may benefit whites more than Blacks
- 09:21, 5 December 2023 diff hist −203 m Non-white or non-European descent abbreviated the quote
- 09:15, 5 December 2023 diff hist +608 Non-white or non-European descent →Black/African descent: added article citing lower amyloid level in black individuals
- 21:40, 4 December 2023 diff hist −1 m Beneficial (and some negative) Plant/Natural Chemicals →Terms A - E: fixed typo
- 20:41, 4 December 2023 diff hist +323 Gut-Brain Connection: Leaky Gut/Leaky Brain, Microbiome (gut bugs) →Alzheimer’s Disease and gut health: added paper The Microbiota–Gut–Brain Axis and Alzheimer’s Disease: Neuroinflammation Is to Blame?(Ashwinipriyadarshini Megur et al, 24 Dec 2020)
- 20:31, 4 December 2023 diff hist +291 Sleep →Why it is important for ApoE4s: added paper: Sleep Disturbance is Associated With Higher Plasma Aβ Levels in Cognitively Normal Adults—A Population-Based Cross-Sectional Study'''] (Yao Gao et al, 18 Jan 2021)
- 20:21, 4 December 2023 diff hist +858 ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s added subheading on handling parasites well and added paper : Apolipoprotein E4 is associated with improved cognitive function in Amazonian forager-horticulturalists with a high parasite burden] (Benjamin C. Trumble et al, Apr 2017)
- 20:12, 4 December 2023 diff hist +1,246 Gut-Brain Connection: Leaky Gut/Leaky Brain, Microbiome (gut bugs) →Alzheimer’s Disease and gut health: added paper: The Contribution of Gut Microbiota–Brain Axis in the Development of Brain Disorders'''] (Jessica Maiuolo et al, 23 Mar 2021)
- 19:34, 4 December 2023 diff hist +699 Fats, Omega -3(ω-3) & -6(ω-6), DHA and More →Omega 6 to Omega 3 ratio: added paper: he Omega-6/Omega-3 Ratio and Dementia or Cognitive Decline: A Systematic Review on Human Studies and Biological Evidence'''] (Martin Loef and Harald Walach, 1 Mar 2013)
- 19:27, 4 December 2023 diff hist +867 Mitochondria →Other research on mitochondria and Alzheimer’s Disease: added paper: Mitochondrial Functioning and the Relations among Health, Cognition, and Aging: Where Cell Biology Meets Cognitive Science (David Geary, 30 Mar 2021)
- 19:15, 4 December 2023 diff hist +275 Sleep →Why it is important for ApoE4s: added paper: An Update on Obstructive Sleep Apnea for Atherosclerosis: Mechanism, Diagnosis, and Treatment (Jin Chen et al, 8 Apr 2021)
- 18:54, 4 December 2023 diff hist +950 Beneficial (and some negative) Plant/Natural Chemicals →Terms A - E: added paper to curcumin: Curcumin Attenuated Neurotoxicity in Sporadic Animal Model of Alzheimer’s Disease'''] (Ines Elbini et al, 18 May 2021)
- 18:21, 4 December 2023 diff hist +278 Sleep →Why it is important for ApoE4s: added paper: Does Insufficient Sleep Increase the Risk of Developing Insulin Resistance: A Systematic Review'''] (Trisha Singh et al, 26 Mar 2022)
- 18:07, 4 December 2023 diff hist +462 Exercise - Types, Lengths, and Benefits →Exercise and Overall Better Health/Longevity: added article: Understanding how exercise induces systemic metabolic benefits (Olivia Dimmer, ''MedicalXpress'', 16 Mar 2023)
- 17:35, 4 December 2023 diff hist +816 ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Small Vessel Disease (SVD): added article: Cerebral Small Vessel Disease Severity, Progression May Predict Dementia Risk (Sheila Jacobs, ''Neurology Advisor'' 16 May 2023)
- 17:26, 4 December 2023 diff hist +989 Fats, Omega -3(ω-3) & -6(ω-6), DHA and More →Why Omega-3s are important for ApoE4s: added paper: The Effect of Omega-3 Fatty Acids on Sarcopenia: Mechanism of Action and Potential Efficacy'''] (Atiporn Therdyothin et al, 13 Jul 2023)
- 17:18, 4 December 2023 diff hist +407 ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →High Cholesterol (Hypercholesterolemia): added paper: APOE4 is associated with elevated blood lipids and lower levels of innate immune biomarkers in a tropical Amerindian subsistence population (Angela R Garcia et al, 29 Sep 2021)
- 08:01, 4 December 2023 diff hist +132 Ketosis and Ketogenic Diet →Some Videos/audios for more information on ketones and Alzheimer’s: added video link: How Ketosis Can Prevent Alzheimer’s Disease w/ Amy Berger
- 19:32, 3 December 2023 diff hist +584 ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Reduced insulin-degrading enzyme (IDE): added wording to subheading
- 19:28, 3 December 2023 diff hist +47 ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s added subheading reduced insulin-degrading enzyme (IDE)
- 19:24, 3 December 2023 diff hist +657 Insulin Resistance →Take it easy on red meat: added amino acids as potential fctor under red meat current
- 19:11, 3 December 2023 diff hist +2,139 Insulin Resistance →Strategies to Lower Insulin Resistance: added findings of meat contributing to insulin resistance
- 17:30, 3 December 2023 diff hist +741 Mitochondria →Other research on mitochondria and Alzheimer’s Disease: added paper: Mitochondrial DNA and Inflammation in Alzheimer’s Disease (Giacoma Galizzi and Marta Di Carlo, 25 Oct 2023)
- 14:04, 3 December 2023 diff hist +507 Beneficial (and some negative) Plant/Natural Chemicals →Terms Starting Numerically: added 8,8'-Bieckol
- 14:02, 3 December 2023 diff hist +90 Beneficial (and some negative) Plant/Natural Chemicals →Terms P - T: added Phlorotannins
- 14:00, 3 December 2023 diff hist +896 Beneficial (and some negative) Plant/Natural Chemicals →Terms A - E: added Dieckol to terms
- 13:56, 3 December 2023 diff hist +987 Beneficial (and some negative) Plant/Natural Chemicals →Terms A - E: added term Eckol
- 13:52, 3 December 2023 diff hist +36 Beneficial (and some negative) Plant/Natural Chemicals →Terms - Including some beneficial & detrimental compounds and their sources: added Terms starting Numerically
- 13:01, 3 December 2023 diff hist +990 Ketosis and Ketogenic Diet →Additional references on ketosis or the introduction of ketones on cognition /Alzheimer’s: added paper: Does the ketogenic diet improve neurological disorders by influencing gut microbiota? A systematic review (Mahdi Mazandarani et al, 20 Nov 2023)
- 12:54, 3 December 2023 diff hist +649 Beneficial (and some negative) Plant/Natural Chemicals →Terms A - E: added terms Coffee grounds and Caffeic-Acid based Carbon Quantum Dots (CACQDs)
- 13:31, 2 December 2023 diff hist +991 Circadian Rhythm →Deeper Dive into the science: added paper: Research advances in the study of sleep disorders, circadian rhythm disturbances and Alzheimer’s disease, Xiangyang Xiong et al, 17 Aug 2022 current
- 13:45, 21 November 2023 diff hist +890 Beneficial (and some negative) Plant/Natural Chemicals →Deeper dive into the science of natural products and health effects: added just published paper: Polyherbal and Multimodal Treatments: Kaempferol- and Quercetin-Rich Herbs Alleviate Symptoms of Alzheimer’s Disease (Claire Alexander et al, 20 Nov 2023)
- 19:30, 16 November 2023 diff hist +11 ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Saturated Fat Sensitivity
- 19:28, 16 November 2023 diff hist +296 ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Saturated Fat Sensitivity
- 19:25, 16 November 2023 diff hist +518 ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Saturated Fat Sensitivity: added paper Effect of Apolipoprotein E Genotype and Saturated Fat Intake on Plasma Lipids and Myocardial Infarction in the Central Valley of Costa Rica (Yadong Yang et al, Dec 2007)
- 14:12, 16 November 2023 diff hist +511 ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Saturated Fat Sensitivity: added paper: Fat intake at midlife and risk of dementia and Alzheimer's disease: a population-based study (M H Laitinen et al, 2006)
- 14:09, 16 November 2023 diff hist +1,928 ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Saturated Fat Sensitivity: Added paper Effect of Apolipoprotein E Genotype and Diet on Apolipoprotein E Lipidation and Amyloid Peptides Randomized Clinical Trial Angela J. Hanson, MD, et al, Aug 2013)
- 14:00, 16 November 2023 diff hist +1,254 ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Saturated Fat Sensitivity: added paper: Saturated and trans fats and dementia: a systematic review Neal D. Barnard et al, Sept 2014)
- 15:31, 15 November 2023 diff hist −28 Fats, Omega -3(ω-3) & -6(ω-6), DHA and More →Deeper Dive into the Science: added bold font to paper titles
- 15:23, 15 November 2023 diff hist +20 Fats, Omega -3(ω-3) & -6(ω-6), DHA and More →Deeper Dive into the Science: added space and enlarged font in subheadings
- 15:20, 15 November 2023 diff hist +248 Fats, Omega -3(ω-3) & -6(ω-6), DHA and More →Deeper Dive into the Science: removed blog reference & added paper it referred to which is now no longer behind pay wall: Effect of Apolipoprotein E Genotype and Diet on Apolipoprotein E Lipidation and Amyloid Peptides
- 16:12, 18 October 2023 diff hist +643 Gut-Brain Connection: Leaky Gut/Leaky Brain, Microbiome (gut bugs) →Alzheimer’s Disease and gut health: added just published paper: Microbiota from Alzheimer’s patients induce deficits in cognition and hippocampal neurogenesis
- 07:09, 17 October 2023 diff hist +37 m Gut-Brain Connection: Leaky Gut/Leaky Brain, Microbiome (gut bugs) →LEAKY GUT: made lipopolysaccharides (LPS) a subheading
- 16:06, 14 October 2023 diff hist +291 Gut-Brain Connection: Leaky Gut/Leaky Brain, Microbiome (gut bugs) →LEAKY GUT: added paper Dietary fat induced chylomicron-mediated LPS translocation in a bicameral Caco-2cell model published Jan 2023
- 09:01, 13 October 2023 diff hist +6 m Gut-Brain Connection: Leaky Gut/Leaky Brain, Microbiome (gut bugs) →VAGUS NERVE: bold font
- 08:58, 13 October 2023 diff hist +2 m Gut-Brain Connection: Leaky Gut/Leaky Brain, Microbiome (gut bugs) →Some Causes of Leaky Gut: added spaces for consistency
- 08:56, 13 October 2023 diff hist +1 Gut-Brain Connection: Leaky Gut/Leaky Brain, Microbiome (gut bugs) →Some Causes of Leaky Gut: added space
- 08:56, 13 October 2023 diff hist +6 m Gut-Brain Connection: Leaky Gut/Leaky Brain, Microbiome (gut bugs) →LEAKY GUT: added bold font
- 08:52, 13 October 2023 diff hist −9 m Gut-Brain Connection: Leaky Gut/Leaky Brain, Microbiome (gut bugs) →Introduction: swapped paragraphs for more logical flow
- 08:47, 13 October 2023 diff hist +39 m Gut-Brain Connection: Leaky Gut/Leaky Brain, Microbiome (gut bugs) →Introduction: fixed link
- 08:46, 13 October 2023 diff hist +35 m Gut-Brain Connection: Leaky Gut/Leaky Brain, Microbiome (gut bugs) →Introduction: bolded the font
- 08:45, 13 October 2023 diff hist +33 m Gut-Brain Connection: Leaky Gut/Leaky Brain, Microbiome (gut bugs) →Introduction: added link to ApoE4.info wiki on Vagus Nerve
- 10:26, 11 October 2023 diff hist +590 Mitochondria →Proton Pump Inhibitors (Prilosec, Prevacid, Nexium, Losec): added just published paper on PPIs, Proton pump inhibitors and dementia: A nationwide population-based study (Nelsan Pourhadi et al, 5 Oct 2023)
- 08:32, 5 October 2023 diff hist +156 Beneficial (and some negative) Plant/Natural Chemicals →Flavonoids: added most common Anthocyanins
- 08:25, 5 October 2023 diff hist +1,091 Beneficial (and some negative) Plant/Natural Chemicals →Terms U - Z: added term urolithins
- 08:07, 5 October 2023 diff hist +693 Beneficial (and some negative) Plant/Natural Chemicals →Terms A - E: added term Ellagitannins
- 08:54, 1 October 2023 diff hist +359 Coffee (and caffeine) →Theoretical concerns: added caution on caffeine and added link to Circadian Rhythm page
- 08:42, 1 October 2023 diff hist +137 Coffee (and caffeine) →Introduction: added 4 constituents of coffee that have been linked to aiding with cognition: phenolic acids (especially chlorogenic acid), tannins (tannic acid), trigonelline (an alkaloid), caffeine (an alkaloid)
- 07:59, 1 October 2023 diff hist −3 m Coffee (and caffeine) →Effectiveness
- 07:59, 1 October 2023 diff hist +300 Coffee (and caffeine) →Effectiveness: added reference link to wiki page: Beneficial (and some negative) Plant/Natural Chemicals
- 05:54, 1 October 2023 diff hist −1 m Beneficial (and some negative) Plant/Natural Chemicals →Polyphenols
- 05:53, 1 October 2023 diff hist +438 Beneficial (and some negative) Plant/Natural Chemicals →Polyphenols: added reference to paper of clinical trial finding polyphenols benefitting biological againg
- 07:56, 30 September 2023 diff hist +401 Insulin Resistance →A guide to associated terms: updated terms NAFLD and NASH with MASLD and MASH
- 07:43, 30 September 2023 diff hist +457 Blood Sugar →Non-alcoholic Fatty Liver Disease (NAFLD): updated term NAFLD to what is now called MASLD current
- 09:01, 29 September 2023 diff hist +105 Beneficial (and some negative) Plant/Natural Chemicals →Terms - Including some beneficial & detrimental compounds and their sources: added subheadings to terms section for ease of access
- 08:55, 29 September 2023 diff hist +531 Beneficial (and some negative) Plant/Natural Chemicals →Terms - Including some beneficial & detrimental compounds and their sources: added term Rosmarinic acid
- 08:49, 29 September 2023 diff hist +451 Beneficial (and some negative) Plant/Natural Chemicals →Terms - Including some beneficial & detrimental compounds and their sources: added term luteolin
- 08:44, 29 September 2023 diff hist +1,152 Beneficial (and some negative) Plant/Natural Chemicals →Terms - Including some beneficial & detrimental compounds and their sources: added term caffeine
- 08:32, 29 September 2023 diff hist +492 Beneficial (and some negative) Plant/Natural Chemicals →Terms - Including some beneficial & detrimental compounds and their sources: added term Chlorogenic acid
- 08:20, 29 September 2023 diff hist +560 Beneficial (and some negative) Plant/Natural Chemicals →Terms - Including some beneficial & detrimental compounds and their sources: added term Trigonelline
- 09:38, 21 September 2023 diff hist +1,482 Beneficial (and some negative) Plant/Natural Chemicals →Deeper dive into the science of natural products and health effects: added Paper Comprehensive Review of Nutraceuticals against Cognitive Decline Associated with Alzheimer’s Disease published 20 Sep 2023
- 08:23, 20 September 2023 diff hist +3 m Beneficial (and some negative) Plant/Natural Chemicals fixed misspelling
- 16:17, 19 September 2023 diff hist +561 Vagus Nerve →Cardiovascular diseases: added just published paper: Vagus Nerve Stimulation and Inflammation in Cardiovascular Disease: A State‐of‐the‐Art Review current
- 15:30, 14 September 2023 diff hist +885 ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Decreased Longevity: under the subheading "Decreased Longevity" added paper: Lower mortality risk in APOE4 carriers with normal cognitive ageing (Elizabeth Pirraglia et al, 12 Sep 2023))
- 13:27, 9 September 2023 diff hist +1,025 Exercise - Types, Lengths, and Benefits →Exercise and the Brain: added paper published 8 Sep 2023: Irisin reduces amyloid-β by inducing the release of neprilysin from astrocytes following downregulation of ERK-STAT3 signaling
- 08:00, 6 September 2023 diff hist 0 m Ketosis and Ketogenic Diet →Additional references on ketosis or the introduction of ketones on cognition /Alzheimer’s: fixed letter
- 07:44, 6 September 2023 diff hist +573 Ketosis and Ketogenic Diet →Additional references on ketosis or the introduction of ketones on cognition /Alzheimer’s: added paper: Triangulating evidence from observational and Mendelian randomization studies of ketone bodies for cognitive performance (Wichanon Sae-jie et al, 4 Sep 2023)
- 15:48, 1 September 2023 diff hist +595 Beneficial (and some negative) Plant/Natural Chemicals →Deeper dive into the science of natural products and health effects: added paper: Hericerin derivatives activates a pan-neurotrophic pathway in central hippocampal neurons converging to ERK1/2 signaling enhancing spatial memory
- 15:20, 1 September 2023 diff hist +367 Cannabinoids: CBD, CBN, THC. Also HEMP & Marijuana (Cannabis) →Marijuana: added reference to paper that found significantly higher levels of metals like lead & cadmium in marijuana users
- 15:48, 23 August 2023 diff hist +839 Beneficial (and some negative) Plant/Natural Chemicals →Deeper dive into the science of natural products and health effects: added paper Potential Benefits of Nobiletin, A Citrus Flavonoid, against Alzheimer’s Disease and Parkinson’s Disease (Akira Nakajima and Yasushi Ohizumi, Jul 2019)
- 15:43, 23 August 2023 diff hist +574 Beneficial (and some negative) Plant/Natural Chemicals →Terms - Including some beneficial & detrimental compounds and their sources: added nobiletin
- 13:31, 18 August 2023 diff hist +401 Beneficial (and some negative) Plant/Natural Chemicals →Terms - Including some beneficial & detrimental compounds and their sources: added term Polysaccharides
- 13:19, 18 August 2023 diff hist +996 Beneficial (and some negative) Plant/Natural Chemicals →Deeper dive into the science of natural products and health effects: added paper Potential Beneficial Effects and Pharmacological Properties of Ergosterol, a Common Bioactive Compound in Edible Mushrooms
- 13:16, 18 August 2023 diff hist +563 Beneficial (and some negative) Plant/Natural Chemicals →Terms - Including some beneficial & detrimental compounds and their sources: added term Ergosterol
- 13:02, 18 August 2023 diff hist −1 m Beneficial (and some negative) Plant/Natural Chemicals →Terms - Including some beneficial & detrimental compounds and their sources: deleted extra space
- 13:02, 18 August 2023 diff hist +563 Beneficial (and some negative) Plant/Natural Chemicals →Terms - Including some beneficial & detrimental compounds and their sources: added term Erinacines
- 12:45, 18 August 2023 diff hist +1,242 Beneficial (and some negative) Plant/Natural Chemicals →Deeper dive into the science of natural products and health effects: added paper, Ergothioneine, a dietary antioxidant improves amyloid beta clearance in the neuroretina of a mouse model of Alzheimer’s disease
- 12:41, 18 August 2023 diff hist +738 Beneficial (and some negative) Plant/Natural Chemicals →Terms - Including some beneficial & detrimental compounds and their sources: added term Ergothioneine
- 11:50, 18 August 2023 diff hist +950 Beneficial (and some negative) Plant/Natural Chemicals →Deeper dive into the science of natural products and health effects: added recently published paper, "Unveiling the Therapeutic Potentials of Mushroom Bioactive Compounds in Alzheimer’s Disease"
- 11:43, 18 August 2023 diff hist +312 Beneficial (and some negative) Plant/Natural Chemicals →Fungi (mushrooms): added graphic on beneficial brain health compounds found in mushrooms
- 11:30, 18 August 2023 diff hist +201 N File:Mushrooms aid brain health.jpg Source: Figure 2 from, "Unveiling the Therapeutic Potentials of Mushroom Bioactive Compounds in Alzheimer’s Disease" (Na Li et al, 7 Aug 2023) https://www.mdpi.com/2304-8158/12/15/2972 current
- 08:36, 1 August 2023 diff hist +1,270 Exercise - Types, Lengths, and Benefits added subheading and discussion on vibration plate therapy
- 18:26, 31 July 2023 diff hist +6 m Exercise - Types, Lengths, and Benefits →Just moving - strolling in the park, tai chi, dancing, gardening, etc.: added bold font
- 18:25, 31 July 2023 diff hist −5 m Exercise - Types, Lengths, and Benefits →Just moving - strolling in the park, tai chi, dancing, gardening, etc.: minor wordsmith
- 18:23, 31 July 2023 diff hist +45 m Exercise - Types, Lengths, and Benefits →Just moving - strolling in the park, tai chi, dancing, gardening, etc.: minor wordsmithing
- 18:22, 31 July 2023 diff hist +33 m Exercise - Types, Lengths, and Benefits →Just moving - strolling in the park, tai chi, dancing, gardening, etc.: minor wordsmithing
- 18:18, 31 July 2023 diff hist +1 m Exercise - Types, Lengths, and Benefits →Why ApoE4s should Exercise: added space
- 18:16, 31 July 2023 diff hist +4 m Exercise - Types, Lengths, and Benefits →Resistance training - Weight lifting, strength training, flex bands, body weight, cross-fit: added pilates
- 18:15, 31 July 2023 diff hist −1 m Exercise - Types, Lengths, and Benefits →Strength training - Weight lifting, resistance training (flex bands, body weight), cross-fit: changed from strength to resistance for consistency of content
- 13:00, 30 July 2023 diff hist 0 m Exercise - Types, Lengths, and Benefits →Muscles and brain health: fixed typo
- 12:44, 30 July 2023 diff hist +704 Exercise - Types, Lengths, and Benefits →Aim for Healthy muscles, not Big muscles: added on oxidative stress from excess exercise
- 12:11, 30 July 2023 diff hist +131 Exercise - Types, Lengths, and Benefits →Muscles and brain health: added graphic illustrating soleus muscle
- 12:05, 30 July 2023 diff hist 0 N File:Soleus muscle2.jpeg current
- 12:04, 30 July 2023 diff hist +8,632 Exercise - Types, Lengths, and Benefits →Resistance training and Cognition: added muscle and bone health influences
- 15:56, 28 July 2023 diff hist +3,257 ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Sleep Apnea: added papers
- 13:59, 28 July 2023 diff hist +662 Beneficial (and some negative) Plant/Natural Chemicals →Terms - Including some beneficial & detrimental compounds and their sources: added term phyllodulcin
- 13:45, 28 July 2023 diff hist +567 Exercise - Types, Lengths, and Benefits →Exercise and ApoE4: added paper: Association between physical activity and episodic memory and the moderating effects of the apolipoprotein E ε4 allele and age
- 13:39, 28 July 2023 diff hist +788 Cannabinoids: CBD, CBN, THC. Also HEMP & Marijuana (Cannabis) →Cannabinoids and Alzheimer’s Disease, Neuroprotection, Neurogenesis, and Amyloid-Beta clearance: added paper: Impaired cholesterol transport from aged astrocytes to neurons can be rescued by cannabinoids.
- 14:49, 27 July 2023 diff hist +417 Inflammation & LPS →Inflammation and LPS (lipopolysaccharides): added paper: Association between an inflammatory biomarker score and future dementia diagnosis in the population-based UK Biobank cohort of 500,000 people current
- 07:37, 26 July 2023 diff hist +18 m Bredesen Protocol →Papers that include discussion of ApoE4: bold font fixes current
- 09:46, 22 July 2023 diff hist +518 Gut-Brain Connection: Leaky Gut/Leaky Brain, Microbiome (gut bugs) →Alzheimer’s Disease and gut health: added paper The gut microbiota-derived metabolite trimethylamine N-oxide is elevated in Alzheimer’s disease (Nicholas M. Vogt et al, 22 Dec 2018)
- 09:42, 22 July 2023 diff hist +636 Gut-Brain Connection: Leaky Gut/Leaky Brain, Microbiome (gut bugs) →Alzheimer’s Disease and gut health: added paper Alzheimer’s disease and gut microbiota: does trimethylamine N-oxide (TMAO) play a role? (Pablo Arrona Cardoza et al, Feb 2022)
- 09:38, 22 July 2023 diff hist +317 Gut-Brain Connection: Leaky Gut/Leaky Brain, Microbiome (gut bugs) →Gut Dybiosis: Added possible association of TMAO to Alzheimer's
- 13:38, 21 July 2023 diff hist −38 Bredesen Protocol →Papers that include discussion of ApoE4: cleaned up
- 13:01, 21 July 2023 diff hist +1 Bredesen Protocol →Dr Bredesen's Papers: added space
- 13:01, 21 July 2023 diff hist +667 Bredesen Protocol →Papers that address Dr Bredesen’s protocol: added recently published paper: Observed Improvement in Cognition During a Personalized Lifestyle Intervention in People with Cognitive Decline
- 12:12, 20 July 2023 diff hist +35 m Gut-Brain Connection: Leaky Gut/Leaky Brain, Microbiome (gut bugs) →Introduction: added (Janet M. Sasso et al, 8 May 2023) to paper
- 08:04, 12 July 2023 diff hist +1,201 Gut-Brain Connection: Leaky Gut/Leaky Brain, Microbiome (gut bugs) →Alzheimer’s Disease and gut health: added just published paper: Gut microbiota regulates blood-cerebrospinal fluid barrier function and Aβ pathology
- 08:05, 8 July 2023 diff hist +671 Circadian Rhythm →Deeper Dive into the science: added just published paper: Predictor of cognitive impairment: metabolic syndrome or circadian syndrome
- 08:49, 6 July 2023 diff hist +307 Bredesen Protocol →Introduction: added PreCode Protocol
- 11:51, 5 July 2023 diff hist +430 Exercise - Types, Lengths, and Benefits →Exercise and ApoE4: added paper: Association between healthy lifestyle and memory decline in older adults: 10 year, population based, prospective cohort study
- 11:47, 5 July 2023 diff hist +583 Exercise - Types, Lengths, and Benefits →Exercise and ApoE4: under Exercise and ApoE4 added paper: Effects of Sex, APOE4, and Lifestyle Activities on Cognitive Reserve in Older Adults
- 11:42, 5 July 2023 diff hist +457 Exercise - Types, Lengths, and Benefits →Deeper Dive into the Science: under Exercise and ApoE4 added paper: Midlife Lifestyle Activities Moderate APOE ε4 Effect on in vivo Alzheimer’s Disease Pathologies
- 09:04, 4 July 2023 diff hist +27 Coconut Oil, MCT oil, and other Ketone/Cognition Boosters (salts, esters) →Ketone salts: added Dr veech passed away at 84. current
- 09:03, 4 July 2023 diff hist +47 Coconut Oil, MCT oil, and other Ketone/Cognition Boosters (salts, esters) →Ketone esters: added a ketone ester product Kenetick
- 16:09, 3 July 2023 diff hist +65 m Beneficial (and some negative) Plant/Natural Chemicals →Terms - Including some beneficial & detrimental compounds and their sources: added link to ApoE4.info wiki article Turmeric and curcumin
- 13:51, 3 July 2023 diff hist +814 Coconut Oil, MCT oil, and other Ketone/Cognition Boosters (salts, esters) →Deeper Dive into the Science: added Jeff Volek as a ketone expert
- 08:21, 2 July 2023 diff hist −1 m Ketosis and Ketogenic Diet →Some Videos/audios for more information on ketones and Alzheimer’s: closed parentheses
- 08:20, 2 July 2023 diff hist +819 Ketosis and Ketogenic Diet →Some Videos/audios for more information on ketones and Alzheimer’s
- 07:43, 2 July 2023 diff hist +221 Insulin Resistance in the brain →Why is it important for ApoE ε4s?: added video Dr. Nadir Ali - 'Insulin resistance and ApoE4 - A Perfect Storm'
- 14:05, 1 July 2023 diff hist −123 m Ketosis and Ketogenic Diet Reverted edits by Officespace (talk) to last revision by Theresab Tag: Rollback
- 08:34, 26 June 2023 diff hist +17 m Cannabinoids: CBD, CBN, THC. Also HEMP & Marijuana (Cannabis) →Marijuana: added "in certain states
- 08:28, 26 June 2023 diff hist 0 m Cannabinoids: CBD, CBN, THC. Also HEMP & Marijuana (Cannabis) →Introduction: fixed typo
- 17:48, 25 June 2023 diff hist +159 m Beneficial (and some negative) Plant/Natural Chemicals →Terms - Including some beneficial & detrimental compounds and their sources: added to psilocybin that it is believed to promote neuroplasticity, but this is yet to be proven in humans
- 11:10, 23 June 2023 diff hist +2,592 Vagus Nerve →Tapping the Vagus Nerve to Help Us Heal: added recently published paper: Modulating heart rate oscillation affects plasma amyloid beta and tau levels in younger and older adults
- 16:16, 22 June 2023 diff hist +1,040 Cannabinoids: CBD, CBN, THC. Also HEMP & Marijuana (Cannabis) →Cannabinoids and Alzheimer’s Disease, Neuroprotection, Neurogenesis, and Amyloid-Beta clearance: added article annabis-Derived Agent SCI-110 Continues to Show Positive Impacts on Alzheimer Agitation
- 18:20, 11 June 2023 diff hist +1,273 Non-white or non-European descent added southern italians and a paper
- 13:38, 11 June 2023 diff hist −1 m Cannabinoids: CBD, CBN, THC. Also HEMP & Marijuana (Cannabis) →Cannabinoids and Alzheimer’s Disease, Neuroprotection, Neurogenesis, and Amyloid-Beta clearance: deleted extra "s'
- 13:30, 11 June 2023 diff hist +1 m Cannabinoids: CBD, CBN, THC. Also HEMP & Marijuana (Cannabis) →Introduction: added an "n" that was left out
- 13:04, 11 June 2023 diff hist +1 m Cannabinoids: CBD, CBN, THC. Also HEMP & Marijuana (Cannabis) →A guide to associated terms: added a space
- 13:00, 11 June 2023 diff hist −17 Cannabinoids: CBD, CBN, THC. Also HEMP & Marijuana (Cannabis) →A Deeper dive into areas of interest to ApoE4 carriers: edited intro to paper on CBN
- 12:57, 11 June 2023 diff hist +288 Cannabinoids: CBD, CBN, THC. Also HEMP & Marijuana (Cannabis) →Marijuana or products containing THC: added Given the lack of medical research in this area, ApoE4.info neither advocates nor opposes the use of products containing THC.
- 12:56, 11 June 2023 diff hist +653 Cannabinoids: CBD, CBN, THC. Also HEMP & Marijuana (Cannabis) →Bioavailability: added cation on vaping & paper on impaired BBB
- 12:52, 11 June 2023 diff hist +1,129 Cannabinoids: CBD, CBN, THC. Also HEMP & Marijuana (Cannabis) →A guide to associated terms: Added the cannabinoid CBN
- 12:36, 11 June 2023 diff hist +911 Cannabinoids: CBD, CBN, THC. Also HEMP & Marijuana (Cannabis) →Marijuana: added Syndos as FDA approved liquid cannabinoid and elaborated on Schedule I drug
- 12:20, 11 June 2023 diff hist +66 Cannabinoids: CBD, CBN, THC. Also HEMP & Marijuana (Cannabis) →Cannabis: elaborated that cannabis is a plant, not a cannabinoid
- 12:17, 11 June 2023 diff hist +1,354 Cannabinoids: CBD, CBN, THC. Also HEMP & Marijuana (Cannabis) →Intro to cannabis and health benefits: added cannabinoid CBN and disclaimer this article neither supports or condems cannabis products
- 05:58, 31 May 2023 diff hist +287 m Main Page added graphic of ApoE4, 3 & 2 timeline
- 05:47, 31 May 2023 diff hist 0 N File:How long has ApoE4 been around.jpg current
- 08:02, 20 May 2023 diff hist −148 m Mitochondria →Cigarette smoke, marijuana smoke, and second hand smoke: deleted dupe
- 08:37, 16 May 2023 diff hist +10 m ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Hypertriglyceridemia: added bold & italics
- 09:34, 15 May 2023 diff hist +29 m Gut-Brain Connection: Leaky Gut/Leaky Brain, Microbiome (gut bugs) →VAGUS NERVE: added ApoE4.info wiki article
- 09:32, 15 May 2023 diff hist +29 m Gut-Brain Connection: Leaky Gut/Leaky Brain, Microbiome (gut bugs) →Addressing a Leaky Gut: added ApoE4.info wiki article
- 09:31, 15 May 2023 diff hist +29 m Gut-Brain Connection: Leaky Gut/Leaky Brain, Microbiome (gut bugs) →Addressing a Leaky Gut: added ApoE4.info wiki article
- 09:29, 15 May 2023 diff hist −149 m Gut-Brain Connection: Leaky Gut/Leaky Brain, Microbiome (gut bugs) →Glyphosate: fixed link
- 09:29, 15 May 2023 diff hist +152 Gut-Brain Connection: Leaky Gut/Leaky Brain, Microbiome (gut bugs) →Glyphosate
- 09:25, 15 May 2023 diff hist +261 m Gut-Brain Connection: Leaky Gut/Leaky Brain, Microbiome (gut bugs) →From leaky gut to leaky brain: added reference to ApoE4 BBB breakdown from Other conditions wiki article
- 09:21, 15 May 2023 diff hist +28 m Gut-Brain Connection: Leaky Gut/Leaky Brain, Microbiome (gut bugs) →LEAKY GUT: added ApoE4.info wiki article
- 09:17, 15 May 2023 diff hist −4 m Gut-Brain Connection: Leaky Gut/Leaky Brain, Microbiome (gut bugs) →LEAKY GUT: substituted sometimes with often
- 09:16, 15 May 2023 diff hist +1 m Gut-Brain Connection: Leaky Gut/Leaky Brain, Microbiome (gut bugs) →LEAKY GUT: added s because plural
- 08:39, 15 May 2023 diff hist +28 m ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Slowed brain glucose uptake: added ApoE4.info wiki article
- 08:39, 15 May 2023 diff hist +28 m ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Issues of the Brain: added ApoE4.info wiki article
- 08:37, 15 May 2023 diff hist +47 m ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Sleep Apnea: added bold font to quote
- 08:36, 15 May 2023 diff hist +31 m ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Gut Microbiota Differences: added ApoE4.info wiki
- 08:34, 15 May 2023 diff hist +31 m ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Mitochondrial dysfunction susceptibility: added ApoE4.info wiki article
- 08:26, 15 May 2023 diff hist 0 m ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Vascular Dementia: swapped study for paper
- 08:24, 15 May 2023 diff hist 0 m ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Issues of the Brain: minor typo fix
- 08:19, 15 May 2023 diff hist −9 m ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Introduction: minor wordsmith
- 18:16, 14 May 2023 diff hist +1 m ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Decreased Longevity: clean up
- 18:15, 14 May 2023 diff hist −24 m ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Gallstones: clean up
- 17:59, 14 May 2023 diff hist −1 m ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Sleep Apnea: clean up
- 17:58, 14 May 2023 diff hist −23 m ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Gut Microbiota Differences: clean up
- 17:53, 14 May 2023 diff hist −19 m ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Impaired Autophagy: clean up
- 17:52, 14 May 2023 diff hist −15 m ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Mitochondrial dysfunction susceptibility: clean up
- 17:48, 14 May 2023 diff hist +33 m ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Blood Brain Barrier (BBB) Breakdown/Leakage
- 17:42, 14 May 2023 diff hist +25 m ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Cerebral amyloid angiopathy (CAA): clean up
- 17:37, 14 May 2023 diff hist +15 m ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Small Vessel Disease (SVD): clean up
- 17:34, 14 May 2023 diff hist +18 m ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Cerebral atherosclerosis (AS): clean up
- 17:33, 14 May 2023 diff hist +23 m ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Parkinson's Disease Dementia: clean up
- 17:30, 14 May 2023 diff hist +12 m ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Vascular Dementia: clean up
- 17:28, 14 May 2023 diff hist +25 m ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Issues of the Brain: clean up
- 17:18, 14 May 2023 diff hist −16 m ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Heightened Immune response/ Infectious disease susceptibility: clean up
- 17:14, 14 May 2023 diff hist −51 ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Cardiovascular Disease (CVD): clean up
- 17:03, 14 May 2023 diff hist +8 m ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Saturated Fat Sensitivity: clean up
- 17:02, 14 May 2023 diff hist −34 m ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Hypertriglyceridemia: clean up
- 16:59, 14 May 2023 diff hist +42 m ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →High Cholesterol (Hypercholesterolemia): clean up
- 16:54, 14 May 2023 diff hist +20 ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Introduction: clean up
- 15:07, 14 May 2023 diff hist +2,161 ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s added subheading of sleep apnea
- 13:46, 14 May 2023 diff hist +3,273 ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s added subsection on autophagy impairment
- 13:00, 14 May 2023 diff hist +3,966 ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s added mitochondrial dysfunction susceptibility
- 12:41, 14 May 2023 diff hist +392 ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Slowed brain glucose uptake: added another reference
- 12:32, 14 May 2023 diff hist +57 m Main Page →Other health conditions besides (or maybe contributing to) Alzheimer's: updated
- 08:50, 14 May 2023 diff hist +11 m ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Immune response/ Infectious disease susceptibility: added Heightened to immune response
- 08:49, 14 May 2023 diff hist +3,720 ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s added subheading on gut microbiota
- 08:08, 14 May 2023 diff hist +433 ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s added saturated fat sensitivity
- 19:44, 13 May 2023 diff hist +1,605 ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Blood Brain Barrier (BBB) Breakdown/Leakage: added reference and quote
- 19:36, 13 May 2023 diff hist +3,501 ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Issues of the Brain: added slowed brain glucose uptake
- 17:54, 13 May 2023 diff hist +2,639 ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Immune response/ Infectious disease susceptibility: added quotes on inflammation from paper APOE Alleles and Diet in Brain Aging and Alzheimer’s Disease
- 17:43, 13 May 2023 diff hist +1 m ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s moved gallstones to end
- 17:42, 13 May 2023 diff hist +27 m Main Page fixed heading
- 09:55, 13 May 2023 diff hist +23 ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →High Cholesterol: added Hypercholesterolemia to heading
- 09:51, 13 May 2023 diff hist +1,343 ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Cardiovascular Disease (CVD): added terms and a paper
- 09:39, 13 May 2023 diff hist +1,360 ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s added section on hypertriglyceridemia
- 09:23, 13 May 2023 diff hist −352 ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Hypercholesterolemia (High Cholesterol): wordsmithed somewhat for better seque to hypertriglyceridemia
- 09:09, 13 May 2023 diff hist +207 N File:ApoE4 triglycerides.jpg Source: https://www.frontiersin.org/articles/10.3389/fnagi.2020.00150/full APOE Alleles and Diet in Brain Aging and Alzheimer’s Disease (Hussein N. Yassine and Caleb E. Finch, 10 June 2020) current
- 08:28, 11 May 2023 diff hist +330 Fats, Omega -3(ω-3) & -6(ω-6), DHA and More →A deeper dive into the science on Omega-3s: added Dr Rhonda Patrick's article on Omega-3s under deeper dive
- 08:23, 11 May 2023 diff hist +582 Fats, Omega -3(ω-3) & -6(ω-6), DHA and More →Strategies for increasing Omega-3s: added Algal oils reference for vegans
- 08:12, 11 May 2023 diff hist +508 Gut-Brain Connection: Leaky Gut/Leaky Brain, Microbiome (gut bugs) →Introduction: added just published review article: Gut Microbiome–Brain Alliance: A Landscape View into Mental and Gastrointestinal Health and Disorders
- 09:57, 7 May 2023 diff hist −1 m Gut-Brain Connection: Leaky Gut/Leaky Brain, Microbiome (gut bugs) →Alzheimer’s Disease and gut health: removed extra space
- 19:53, 6 May 2023 diff hist +938 Circadian Rhythm →Circadian Rhythm and Alzheimer’s Disease/the Brain: added recently published paper: Gut microbiota and circadian rhythm in Alzheimer’s disease pathophysiology: a review and hypothesis on their association
- 19:48, 6 May 2023 diff hist +1,577 Gut-Brain Connection: Leaky Gut/Leaky Brain, Microbiome (gut bugs) →Alzheimer’s Disease and gut health: added two recently publoshed papers
- 07:38, 4 May 2023 diff hist +32 m Bredesen Protocol →Dr Bredesen's research: added subheadings under Dr Bredesen's research
- 07:36, 4 May 2023 diff hist +8 m Bredesen Protocol →Resources: turned table of recode tests into a heading
- 07:31, 4 May 2023 diff hist −33 m Bredesen Protocol →Dr Bredesen's research: changed subheading titles
- 09:49, 3 May 2023 diff hist +5,684 Bredesen Protocol →Dr Bredesen's research: rearranged papers separating protocol and papers addressing ApoE4
- 13:27, 17 April 2023 diff hist +654 Beneficial (and some negative) Plant/Natural Chemicals →Deeper dive into the science of natural products and health effects: added paper Carotenoid-Rich Brain Nutrient Pattern Is Positively Correlated With Higher Cognition and Lower Depression in the Oldest Old With No Dementia
- 09:36, 17 April 2023 diff hist +354 Beneficial (and some negative) Plant/Natural Chemicals →Deeper dive into the science of natural products and health effects: added paper Long-Term Intake of Dietary Carotenoids Is Positively Associated with Late-Life Subjective Cognitive Function in a Prospective Study in US Women
- 16:23, 11 April 2023 diff hist −9 m ApoE ε4 and health conditions besides (or maybe contributing to) Alzheimer’s →Blood Brain Barrier (BBB) Leakage: paper no longer behind paywall, changed link
- 07:54, 11 April 2023 diff hist +6 Non-white or non-European descent →Black/African descent: added bold font
- 07:53, 11 April 2023 diff hist +262 Non-white or non-European descent →Black/African descent: added paper A locus at 19q13.31 significantly reduces the ApoE ε4 risk for Alzheimer’s Disease in African Ancestry
- 08:21, 8 April 2023 diff hist −1 m Sleep →A deeper dive into the science: removed stray mark, rearranged references by date published
- 08:20, 8 April 2023 diff hist +374 m Sleep →A deeper dive into the science: added just published paper: "Distinct cognitive changes in male patients with obstructive sleep apnoea without co-morbidities"
- 09:28, 30 March 2023 diff hist +2,434 Circadian Rhythm →Circadian Rhythm and Longevity: added paper Inputs and Outputs of the Mammalian Circadian Clock (Ashley N. Starnes and Jeff R. Jones, 28 Mar 2023)
- 08:08, 30 March 2023 diff hist +1,234 Beneficial (and some negative) Plant/Natural Chemicals →Deeper dive into the science of natural products and health effects: added paper published Mar 21, 2023: Turning Back the Clock: A Retrospective Single-Blind Study on Brain Age Change in Response to Nutraceuticals Supplementation vs. Lifestyle Modifications
- 07:51, 30 March 2023 diff hist +194 Beneficial (and some negative) Plant/Natural Chemicals →Terms - Including some beneficial & detrimental compounds and their sources: added term nutraceutical
- 09:16, 29 March 2023 diff hist +1,301 Gut-Brain Connection: Leaky Gut/Leaky Brain, Microbiome (gut bugs) →Alzheimer’s Disease and gut health: added just published paper: Impact of Gut Microbiota in Brain Ageing: Polyphenols as Beneficial Modulators
- 09:10, 29 March 2023 diff hist +1 Beneficial (and some negative) Plant/Natural Chemicals →Deeper dive into the science of natural products and health effects: added space
- 09:10, 29 March 2023 diff hist +1,301 Beneficial (and some negative) Plant/Natural Chemicals →Deeper dive into the science of natural products and health effects: added just published paper: Impact of Gut Microbiota in Brain Ageing: Polyphenols as Beneficial Modulators
- 09:16, 24 March 2023 diff hist +540 Stress →Stress and the Brain: added study published Dec 2022 current
- 15:43, 15 March 2023 diff hist 0 m From Fructose to Alzheimer's →Introduction to sugar: capitalized letter current
- 09:30, 15 March 2023 diff hist +199 m From Fructose to Alzheimer's →Does fructose affect ApoE4s more?: added reference to footnote
- 09:25, 15 March 2023 diff hist +28 m From Fructose to Alzheimer's →Does fructose affect ApoE4s more?: explained OXPHOS
- 09:07, 15 March 2023 diff hist +110 m From Fructose to Alzheimer's →Introduction to sugar: added liver is only organ in the body that can metabolize fructose in significant amounts
- 08:58, 15 March 2023 diff hist +4 m From Fructose to Alzheimer's →Introduction to sugar: forgot to add link
- 11:10, 11 March 2023 diff hist +284 m From Fructose to Alzheimer's →Fructose and Alzheimer’s Disease: added reference to footnote
- 10:59, 11 March 2023 diff hist +3 m From Fructose to Alzheimer's →Other food and conditions that stimulate fructose production: added missing word "in"
- 10:54, 11 March 2023 diff hist +4 m From Fructose to Alzheimer's →Introduction to sugar: forgot to add link to insulin resistance in brain
- 10:29, 11 March 2023 diff hist +1,134 Beneficial (and some negative) Plant/Natural Chemicals →Deeper dive into the science of natural products and health effects: added recently published paper on carotenoids
- 14:36, 10 March 2023 diff hist +6 From Fructose to Alzheimer's bold font
- 14:34, 10 March 2023 diff hist −11 From Fructose to Alzheimer's deleted "under construction"
- 14:06, 10 March 2023 diff hist +27 From Fructose to Alzheimer's →Fructose and Alzheimer’s Disease: added bold font
- 14:05, 10 March 2023 diff hist 0 From Fructose to Alzheimer's →Dehydration (and a salty diet): fixed bold font
- 14:04, 10 March 2023 diff hist +10 From Fructose to Alzheimer's →About the lead researcher, Richard J. Johnson: explained nephrology
- 14:03, 10 March 2023 diff hist +24 From Fructose to Alzheimer's →This is still a hypothesis: little more clarity
- 14:01, 10 March 2023 diff hist −11 From Fructose to Alzheimer's →Fructose and Alzheimer’s Disease: added graphic
- 13:56, 10 March 2023 diff hist 0 File:Fructose vs AD2.jpg Theresab uploaded a new version of File:Fructose vs AD2.jpg current
- 13:53, 10 March 2023 diff hist 0 N File:Fructose vs AD2.jpg
- 13:50, 10 March 2023 diff hist +8 m From Fructose to Alzheimer's →Fructose: clarification
- 13:48, 10 March 2023 diff hist 0 m From Fructose to Alzheimer's →Dehydration (and a salty diet): fixed awkward wording
- 13:47, 10 March 2023 diff hist −6 m From Fructose to Alzheimer's →Dehydration (and a salty diet): fixed wording, less awkward
- 13:46, 10 March 2023 diff hist +6 m From Fructose to Alzheimer's →Dehydration (and a salty diet): bold font
- 13:43, 10 March 2023 diff hist −10 m From Fructose to Alzheimer's →Salt: deleted redundancy
- 13:42, 10 March 2023 diff hist +2 m From Fructose to Alzheimer's →Other food and conditions that stimulate fructose production: added needed verb
- 13:39, 10 March 2023 diff hist +19 m From Fructose to Alzheimer's →Effects of Fructose on the brain: word smith
- 13:35, 10 March 2023 diff hist +14 m From Fructose to Alzheimer's wordsmith
- 13:32, 10 March 2023 diff hist −5 From Fructose to Alzheimer's reworded something that sounded awkward
- 13:22, 10 March 2023 diff hist −6 m Oxalates →Introduction: deleted stray marks
- 13:21, 10 March 2023 diff hist +195 m Oxalates →Introduction: added cross ref to Beneficial/negative plant/natural chemical wiki article
- 13:09, 10 March 2023 diff hist +1,791 Exercise - Types, Lengths, and Benefits added section on Blood Flow restriction bands
- 11:45, 10 March 2023 diff hist +1,288 From Fructose to Alzheimer's →Fructose: added references to quoted footnotes
- 10:52, 10 March 2023 diff hist +11 From Fructose to Alzheimer's made font bigger for emphasis
- 10:51, 10 March 2023 diff hist +37 From Fructose to Alzheimer's added bold font to caption
- 10:33, 10 March 2023 diff hist 0 File:Dietary Sources of Fructose3.jpg Theresab uploaded a new version of File:Dietary Sources of Fructose3.jpg current
- 10:32, 10 March 2023 diff hist 0 File:Dietary Sources of Fructose3.jpg Theresab uploaded a new version of File:Dietary Sources of Fructose3.jpg
- 10:16, 10 March 2023 diff hist +6 From Fructose to Alzheimer's →About the lead researcher, Richard J. Johnson: bold font
- 10:15, 10 March 2023 diff hist −5 From Fructose to Alzheimer's →This is still a hypothesis: deleted redundancy
- 10:14, 10 March 2023 diff hist 0 From Fructose to Alzheimer's →This is still a hypothesis: deleted extra letter
- 10:13, 10 March 2023 diff hist +1 From Fructose to Alzheimer's →This is still a hypothesis
- 10:13, 10 March 2023 diff hist −321 From Fructose to Alzheimer's →Traumatic Brain Injury (TBI): deleted prompt to insert graphic
- 10:12, 10 March 2023 diff hist +411 From Fructose to Alzheimer's →Fructose: added graphic
- 10:08, 10 March 2023 diff hist +251 N File:Endogenous sources of fructose2.jpg Source: [https://onlinelibrary.wiley.com/doi/10.1111/joim.12993 Fructose metabolism as a common evolutionary pathway of survival associated with climate change, food shortage and droughts ](R. J. Johnson et al, 17 October 2019), Table 1 current
- 10:06, 10 March 2023 diff hist +33 From Fructose to Alzheimer's →Dehydration (and a salty diet): added graphic
- 10:03, 10 March 2023 diff hist +57 N File:Sources of Sodium2.jpg Source: https://www.cdc.gov/salt/food.htm current
- 10:01, 10 March 2023 diff hist +2 From Fructose to Alzheimer's →Salt: fixed wording and deleted extra letter
- 10:00, 10 March 2023 diff hist +58 From Fructose to Alzheimer's →Salt: added graphic
- 09:59, 10 March 2023 diff hist +326 N File:Salt triggers fructose2.jpg Source: Richard J. Johnson MD, 24 Feb 2023, A Biological Switch that Drives Obesity, Metabolic Syndrome and other Conditions [PowerPoint slides] Low Carb Denver 2023 Health & Nutrition Conference, https://www.eventbrite.com/e/low-carb-denver-2023-health-nutrition-conference-watch-on-demand-tickets-331263166047 current
- 09:58, 10 March 2023 diff hist +18 From Fructose to Alzheimer's →Other food and conditions that stimulate fructose production: added to caption
- 09:55, 10 March 2023 diff hist +263 From Fructose to Alzheimer's →Other food and conditions that stimulate fructose production: added reference
- 09:50, 10 March 2023 diff hist +41 From Fructose to Alzheimer's →Introduction to sugar: added bold font
- 09:49, 10 March 2023 diff hist +12 From Fructose to Alzheimer's →Survival Pathway Triggered by Fructose: added bold font
- 09:48, 10 March 2023 diff hist +20 From Fructose to Alzheimer's →Effects of Fructose on the brain: added full words instead of abbreviations
- 09:47, 10 March 2023 diff hist +12 From Fructose to Alzheimer's →Effects of Fructose on the brain: added bold font