Increase NGF

The sixteenth intervention to reverse mild Alzheimer's in the Bredesen Protocol is:

Goal: Increase NGF

Approach: H. erinaceus or ALCAR

NGF (Nerve growth factor) prevents or reduces neuronal degeneration in animal models of neurodegenerative diseases. These encouraging results in animals have led to several clinical trials in humans.

Hericium erinaceus (Lion's mane) 500mg twice per day. A clinical trial using this herb for MCI (mild cognitive impairment) was published in 2009.

Acetyl-L-carnitine (ALCAR) 500mg per day.

References

• Nerve growth factor-inducing activity of Hericium erinaceus in 1321N1 human astrocytoma cells
• Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial
• Acetyl-L-carnitine treatment increases nerve growth factor levels and choline acetyltransferase activity in the central nervous system of aged rats
• Improving and Retaining Memory Function Feb 15, 2015

Next Intervention

The next intervention in the Bredesen Protocol is Provide synaptic structural components.