Optimize antioxidants

The eighteenth intervention to reverse mild Alzheimer's in the Bredesen Protocol is:

Goal: Optimize antioxidants

Approach: Mixed tocopherols and tocotrienols, Selenium, blueberries, NAC, ascorbate, a-lipoic acid

Vitamin E 400 IU (best to use mixed tocopherols, optimally including tocotrienols).

NAC (N-acetylcysteine) 400-500mg (to increase glutathione cellular protection) blocks oxidative damage in Alzheimer's.

Blood brain barrier dysfunction accelerates the rate of degeneration in Alzheimer's by impairing the ability of the brain to concentrate ascorbate (Vitamin C) and other nutrients with neuroprotective properties.

a-lipoic acid can reduce the formation of Alzheimer's disease plaques and increase the production of acetylcholine, an important signaling molecule that is impaired in Alzheimer's disease.

References

• Formulation of a medical food cocktail for Alzheimer's disease: beneficial effects on cognition and neuropathology in a mouse model of the disease
• Improving and Retaining Memory Function Feb 15, 2015
• Blueberries, the well-known 'super fruit,' could help fight Alzheimer's
• Alzheimer's patients with low Selenium in their blood have been found to have more problems with cognitive function.

Next Intervention

The next intervention in the Bredesen Protocol is Optimize Zn:fCu ratio.