Optimize Zn:fCu ratio
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The nineteenth intervention to reverse mild Alzheimer's in the Bredesen Protocol is:
- Goal: Optimize Zn:fCu ratio to 1:1
- Approach: Depends on values obtained
- References: Zinc deficiency and zinc therapy efficacy with reduction of serum free copper in Alzheimer's disease
Zinc is involved in multiple Alzheimer's-related metabolic processes, such as insulin resistance, chronic inflammation, ADAM10 proteolytic activity, and hormonal signaling.
One of the symptoms, signs, and laboratory values suggestive of type 3 Alzheimer's disease is Low serum zinc (<75mcg/dl) or RBC zinc, or high copper:zinc ratio (>1.3)
The next intervention in the Bredesen Protocol is Ensure nocturnal oxygenation.