Difference between revisions of "Optimize mitochondrial function"

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The twenty first intervention to reverse mild Alzheimer's in the [[Bredesen Protocol]] is:
'''Goal''': Optimize mitochondrial function


:'''Goal''': Optimize mitochondrial function
'''Approach''': Look into supplementing with CoQ or ubiquinol, a-lipoic acid, PQQ, NAC, ALCAR, Se, Zn, resveratrol, ascorbate, thiamine.


:'''Approach''': CoQ or ubiquinol, a-lipoic acid, PQQ, NAC, ALCAR, Se, Zn, resveratrol, ascorbate, thiamine
[http://en.wikipedia.org/wiki/Mitochondrion Mitochondria] are the organelles in your cells that generate energy.


:'''References''': [http://www.amazon.com/Disease-Delusion-Conquering-Chronic-Healthier-ebook/dp/B00FJ37DEO?ie=UTF8&btkr=1&ref_=dp-kindle-redirect The Disease Delusion: Conquering the Causes of Illness for a Healthier, Longer and Happier Life]
There are several supplements that can improve mitochondrial activity. Please do talk to your doctor before starting new supplements to make sure you will reduce the chances of interactions with other medicine or supplements you might be taking. We always recommend starting with a low dose to see how it affects you and increasing the dose if needed.


:[https://www.apoe4.info/forums/download/file.php?id=453 Improving and Retaining Memory Function] Feb 15, 2015
* CoQ [http://en.wikipedia.org/wiki/Coenzyme_Q10 Coenzyme Q10] is a molecule in the mitochondria that is essential to producing energy.  [http://en.wikipedia.org/wiki/Ubiquinol Ubiquinol] is its electron-rich (reduced) form that is better [http://www.lifeextension.com/magazine/2007/1/report_coq10/Page-01 absorbed].


[http://en.wikipedia.org/wiki/Mitochondrion Mitochondria] are the organelles in your cells that generate energy.
* [http://alzdiscovery.org/cognitive-vitality/report/ala a-lipoic acid] can reduce the formation of Alzheimer's disease plaques and increase the production of acetylcholine, an important signaling molecule that is impaired in Alzheimer's disease.
CoQ [http://en.wikipedia.org/wiki/Coenzyme_Q10 Coenzyme Q10] is a molecule in the mitochondria that is essential to producing energy. [http://en.wikipedia.org/wiki/Ubiquinol Ubiquinol] is it's electron-rich (reduced) form that is better [http://www.lifeextension.com/magazine/2007/1/report_coq10/Page-01 absorbed].
 
* PQQ ([http://en.wikipedia.org/wiki/Pyrroloquinoline_quinone pyrroloquinoline quinone]) [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212345/ prevents] cognitive deficit caused by oxidative stress in rats.


[http://alzdiscovery.org/cognitive-vitality/report/ala a-lipoic acid] can reduce the formation of Alzheimer's disease plaques and increase the production of acetylcholine, an important signaling molecule that is impaired in Alzheimer's disease.
* NAC ([http://onlinelibrary.wiley.com/doi/10.1002/brb3.208/full N-acetylcysteine]) up to 400-500mg (to increase glutathione cellular protection) blocks oxidative damage in Alzheimer's.


PQQ ([http://en.wikipedia.org/wiki/Pyrroloquinoline_quinone pyrroloquinoline quinone]) [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212345/ prevents] cognitive deficit caused by oxidative stress in rats.
* [http://en.wikipedia.org/wiki/Acetylcarnitine Acetyl-L-carnitine] (ALCAR), up to 500mg per day.


NAC ([http://onlinelibrary.wiley.com/doi/10.1002/brb3.208/full N-acetylcysteine]) 400-500mg (to increase glutathione cellular protection) blocks oxidative damage in Alzheimer's.
* Alzheimer's patients with low Se ([http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147716/ Selenium]) in their blood have been found to have more problems with cognitive function.


[http://en.wikipedia.org/wiki/Acetylcarnitine Acetyl-L-carnitine] (ALCAR) 500mg per day.
* [[Optimize Zn:fCu ratio]]


Alzheimer's patients with low Se ([http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147716/ Selenium]) in their blood have been found to have more problems with cognitive function.
* [http://en.wikipedia.org/wiki/Resveratrol Resveratrol] [http://www.medscape.com/viewarticle/835614 Stabilizes Amyloid in Alzheimer's]


[[Optimize Zn:fCu ratio]]
* Blood brain barrier dysfunction accelerates the rate of degeneration in Alzheimer's by impairing the ability of the brain to concentrate ascorbate ([http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2674290/ Vitamin C]) and other nutrients with neuroprotective properties.


[http://en.wikipedia.org/wiki/Resveratrol Resveratrol] [http://www.medscape.com/viewarticle/851172 Stabilizes Amyloid in Alzheimer's]
* [http://en.wikipedia.org/wiki/Thiamine Thiamine] up to 2.5mg.  Oral thiamine trials have been [http://www.ncbi.nlm.nih.gov/pubmed/22218733 shown] to improve the cognitive function of patients with AD. See [[Thiamine]] at this Wiki for a more in-depth introduction to the literature.


Blood brain barrier dysfunction accelerates the rate of degeneration in Alzheimer's by impairing the ability of the brain to concentrate ascorbate ([http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2674290/ Vitamin C]) and other nutrients with neuroprotective properties.
== References ==


[http://en.wikipedia.org/wiki/Thiamine Thiamine] 2.5mg. Oral thiamine trials have been [http://www.ncbi.nlm.nih.gov/pubmed/22218733 shown] to improve the cognitive function of patients with AD. (This article refers to a prior article which can't be accessed but which is important to evaluate.) A 2010 study, [http://www.ncbi.nlm.nih.gov/pubmed/20385653 Powerful beneficial effects of benfotiamine on cognitive impairment and beta-amyloid deposition in amyloid precursor protein/presenilin-1 transgenic mice] states that 'thiamine treatment exerts little beneficial effect in [Alzheimer's] patients... In the animal Alzheimer's disease model, benfotiamine appears to improve the cognitive function and reduce amyloid deposition via thiamine-independent mechanisms... These results suggest that, unlike many other thiamine-related drugs, benfotiamine may be beneficial for clinical Alzheimer's disease treatment. A 2015 review, [http://www.ncbi.nlm.nih.gov/pubmed/25849949 Role of dietary protein and thiamine intakes on cognitive function in healthy older people: a systematic review.], concludes 'a lack of experimental [human] studies in this area prevents the translation of these dietary messages for optimal cognitive functioning and delaying the decline in cognition with advancing age.' A March 2016 discussion, [http://www.ncbi.nlm.nih.gov/pubmed/26971083 Vitamin B1 (thiamine) and dementia], describes the close connection between thiamine deficiency and hypometabolism of glucose in the brain and concludes 'Elucidating the reasons why the brains of AD patients are functionally thiamine deficient and determining the effects of thiamine restoration may provide critical information to help treat patients with AD.'
* [http://www.amazon.com/Disease-Delusion-Conquering-Chronic-Healthier-ebook/dp/B00FJ37DEO?ie=UTF8&btkr=1&ref_=dp-kindle-redirect The Disease Delusion: Conquering the Causes of Illness for a Healthier, Longer and Happier Life]
* [https://www.apoe4.info/forums/download/file.php?id=453 Improving and Retaining Memory Function] Feb 15, 2015


It appears further studies may be required to show conclusively that thiamine supplementation helps prevent or reverse Alzheimer's-associated cognitive decline in humans. While ensuring optimal thiamine status would seem to be a safe intervention and may help address Alzheimer's-related pathologies, this appears to be more likely when using the benfotiamine form. Here, however, we encounter a potential issue. Other studies caution that benfotiamine may fuel cancer when it is present, and of course we don't always know when cancer is present. See for example [http://www.ncbi.nlm.nih.gov/pubmed/11488910 The effect of thiamine supplementation on tumour proliferation. A metabolic control analysis study], along with [http://www.ncbi.nlm.nih.gov/pubmed/?cmd=historysearch&querykey=14 other such studies at pubmed].


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The next intervention in the [[Bredesen Protocol]] is [[Increase focus]].
'''Return to [[Bredesen_Protocol#Lifestyle_Strategies|Lifestyle Strategies]].'''

Revision as of 09:19, 4 March 2018

Goal: Optimize mitochondrial function

Approach: Look into supplementing with CoQ or ubiquinol, a-lipoic acid, PQQ, NAC, ALCAR, Se, Zn, resveratrol, ascorbate, thiamine.

Mitochondria are the organelles in your cells that generate energy.

There are several supplements that can improve mitochondrial activity. Please do talk to your doctor before starting new supplements to make sure you will reduce the chances of interactions with other medicine or supplements you might be taking. We always recommend starting with a low dose to see how it affects you and increasing the dose if needed.

  • CoQ Coenzyme Q10 is a molecule in the mitochondria that is essential to producing energy. Ubiquinol is its electron-rich (reduced) form that is better absorbed.
  • a-lipoic acid can reduce the formation of Alzheimer's disease plaques and increase the production of acetylcholine, an important signaling molecule that is impaired in Alzheimer's disease.
  • NAC (N-acetylcysteine) up to 400-500mg (to increase glutathione cellular protection) blocks oxidative damage in Alzheimer's.
  • Alzheimer's patients with low Se (Selenium) in their blood have been found to have more problems with cognitive function.
  • Blood brain barrier dysfunction accelerates the rate of degeneration in Alzheimer's by impairing the ability of the brain to concentrate ascorbate (Vitamin C) and other nutrients with neuroprotective properties.
  • Thiamine up to 2.5mg. Oral thiamine trials have been shown to improve the cognitive function of patients with AD. See Thiamine at this Wiki for a more in-depth introduction to the literature.

References


Return to Lifestyle Strategies.

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