Difference between revisions of "Optimize mitochondrial function"

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The twenty first intervention to reverse mild Alzheimer's in the [[Bredesen Protocol]] is:
'''Goal''': Optimize mitochondrial function


:'''Goal''': Optimize mitochondrial function
'''Approach''': Look into supplementing with CoQ or ubiquinol, a-lipoic acid, PQQ, NAC, ALCAR, Se, Zn, resveratrol, ascorbate, thiamine.


:'''Approach''': CoQ or ubiquinol, a-lipoic acid, PQQ, NAC, ALCAR, Se, Zn, resveratrol, ascorbate, thiamine
[http://en.wikipedia.org/wiki/Mitochondrion Mitochondria] are the organelles in your cells that generate energy.
 
There are several supplements that can improve mitochondrial activity. Please do talk to your doctor before starting new supplements to make sure you will reduce the chances of interactions with other medicine or supplements you might be taking. We always recommend starting with a low dose to see how it affects you and increasing the dose if needed.


[http://en.wikipedia.org/wiki/Mitochondrion Mitochondria] are the organelles in your cells that generate energy.
* CoQ [http://en.wikipedia.org/wiki/Coenzyme_Q10 Coenzyme Q10] is a molecule in the mitochondria that is essential to producing energy.  [http://en.wikipedia.org/wiki/Ubiquinol Ubiquinol] is its electron-rich (reduced) form that is better [http://www.lifeextension.com/magazine/2007/1/report_coq10/Page-01 absorbed].
CoQ [http://en.wikipedia.org/wiki/Coenzyme_Q10 Coenzyme Q10] is a molecule in the mitochondria that is essential to producing energy.  [http://en.wikipedia.org/wiki/Ubiquinol Ubiquinol] is it's electron-rich (reduced) form that is better [http://www.lifeextension.com/magazine/2007/1/report_coq10/Page-01 absorbed].


[http://alzdiscovery.org/cognitive-vitality/report/ala a-lipoic acid] can reduce the formation of Alzheimer's disease plaques and increase the production of acetylcholine, an important signaling molecule that is impaired in Alzheimer's disease.
* [http://alzdiscovery.org/cognitive-vitality/report/ala a-lipoic acid] can reduce the formation of Alzheimer's disease plaques and increase the production of acetylcholine, an important signaling molecule that is impaired in Alzheimer's disease.


PQQ ([http://en.wikipedia.org/wiki/Pyrroloquinoline_quinone pyrroloquinoline quinone]) [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212345/ prevents] cognitive deficit caused by oxidative stress in rats.
* PQQ ([http://en.wikipedia.org/wiki/Pyrroloquinoline_quinone pyrroloquinoline quinone]) [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212345/ prevents] cognitive deficit caused by oxidative stress in rats.


NAC ([http://onlinelibrary.wiley.com/doi/10.1002/brb3.208/full N-acetylcysteine]) 400-500mg (to increase glutathione cellular protection) blocks oxidative damage in Alzheimer's.
* NAC ([http://onlinelibrary.wiley.com/doi/10.1002/brb3.208/full N-acetylcysteine]) up to 400-500mg (to increase glutathione cellular protection) blocks oxidative damage in Alzheimer's.


[http://en.wikipedia.org/wiki/Acetylcarnitine Acetyl-L-carnitine] (ALCAR) 500mg per day.
* [http://en.wikipedia.org/wiki/Acetylcarnitine Acetyl-L-carnitine] (ALCAR), up to 500mg per day.


Alzheimer's patients with low Se ([http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147716/ Selenium]) in their blood have been found to have more problems with cognitive function.
* Alzheimer's patients with low Se ([http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147716/ Selenium]) in their blood have been found to have more problems with cognitive function.


[[Optimize Zn:fCu ratio]]
* [[Optimize Zn:fCu ratio]]


[http://en.wikipedia.org/wiki/Resveratrol Resveratrol] [http://www.medscape.com/viewarticle/835614 Stabilizes Amyloid in Alzheimer's]
* [http://en.wikipedia.org/wiki/Resveratrol Resveratrol] [http://www.medscape.com/viewarticle/835614 Stabilizes Amyloid in Alzheimer's]


Blood brain barrier dysfunction accelerates the rate of degeneration in Alzheimer's by impairing the ability of the brain to concentrate ascorbate ([http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2674290/ Vitamin C]) and other nutrients with neuroprotective properties.
* Blood brain barrier dysfunction accelerates the rate of degeneration in Alzheimer's by impairing the ability of the brain to concentrate ascorbate ([http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2674290/ Vitamin C]) and other nutrients with neuroprotective properties.


[http://en.wikipedia.org/wiki/Thiamine Thiamine] 2.5mg.  Oral thiamine trials have been [http://www.ncbi.nlm.nih.gov/pubmed/22218733 shown] to improve the cognitive function of patients with AD. See [[Thiamine]] at this Wiki for a more in-depth introduction to the literature.
* [http://en.wikipedia.org/wiki/Thiamine Thiamine] up to 2.5mg.  Oral thiamine trials have been [http://www.ncbi.nlm.nih.gov/pubmed/22218733 shown] to improve the cognitive function of patients with AD. See [[Thiamine]] at this Wiki for a more in-depth introduction to the literature.


== References ==  
== References ==  
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* [https://www.apoe4.info/forums/download/file.php?id=453 Improving and Retaining Memory Function] Feb 15, 2015
* [https://www.apoe4.info/forums/download/file.php?id=453 Improving and Retaining Memory Function] Feb 15, 2015


== Next Intervention ==


The next intervention in the [[Bredesen Protocol]] is [[Increase focus]].
-----
 
'''Return to [[Bredesen_Protocol#Lifestyle_Strategies|Lifestyle Strategies]].'''

Revision as of 09:19, 4 March 2018

Goal: Optimize mitochondrial function

Approach: Look into supplementing with CoQ or ubiquinol, a-lipoic acid, PQQ, NAC, ALCAR, Se, Zn, resveratrol, ascorbate, thiamine.

Mitochondria are the organelles in your cells that generate energy.

There are several supplements that can improve mitochondrial activity. Please do talk to your doctor before starting new supplements to make sure you will reduce the chances of interactions with other medicine or supplements you might be taking. We always recommend starting with a low dose to see how it affects you and increasing the dose if needed.

  • CoQ Coenzyme Q10 is a molecule in the mitochondria that is essential to producing energy. Ubiquinol is its electron-rich (reduced) form that is better absorbed.
  • a-lipoic acid can reduce the formation of Alzheimer's disease plaques and increase the production of acetylcholine, an important signaling molecule that is impaired in Alzheimer's disease.
  • NAC (N-acetylcysteine) up to 400-500mg (to increase glutathione cellular protection) blocks oxidative damage in Alzheimer's.
  • Alzheimer's patients with low Se (Selenium) in their blood have been found to have more problems with cognitive function.
  • Blood brain barrier dysfunction accelerates the rate of degeneration in Alzheimer's by impairing the ability of the brain to concentrate ascorbate (Vitamin C) and other nutrients with neuroprotective properties.
  • Thiamine up to 2.5mg. Oral thiamine trials have been shown to improve the cognitive function of patients with AD. See Thiamine at this Wiki for a more in-depth introduction to the literature.

References


Return to Lifestyle Strategies.

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