Difference between revisions of "Optimize sleep"

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:'''Approach''': 8 hr sleep per night; melatonin 0.5mg po qhs; Trp 500mg po 3x/wk if awakening. Exclude sleep apnea.
:'''Approach''': 8 hr sleep per night; melatonin 0.5mg po qhs; Trp 500mg po 3x/wk if awakening. Exclude sleep apnea.


:'''Reference''': [http://www.researchgate.net/publication/259587123_Role_of_melatonin_supplementation_in_neurodegenerative_disorders Role of melatonin supplementation in neurodegenerative disorders]
:'''References''': [http://www.researchgate.net/publication/259587123_Role_of_melatonin_supplementation_in_neurodegenerative_disorders Role of melatonin supplementation in neurodegenerative disorders]


[http://en.wikipedia.org/wiki/Melatonin Melatonin]
:[https://www.apoe4.info/forums/download/file.php?id=453 Improving and Retaining Memory Function] Feb 15, 2015


Trp ([http://en.wikipedia.org/wiki/Tryptophan Tryptophan])
Get at least 7 hours of sleep each night (preferably 8). Taking [http://en.wikipedia.org/wiki/Melatonin melatonin] before bed can be helpful (0.5 to 1mg; this can be purchased over the counter).  If you awaken and can't go back to sleep in the middle of the night, you can add [http://en.wikipedia.org/wiki/Tryptophan tryptophan] (500mg) or [https://en.wikipedia.org/wiki/5-Hydroxytryptophan 5-hydroxytryptophan] (100mg) at bedtime.


[http://en.wikipedia.org/wiki/Sleep_apnea Sleep Apnea]
[http://en.wikipedia.org/wiki/Sleep_apnea Sleep Apnea]


The next intervention is [[Exercise]].
The next intervention is [[Exercise]].

Revision as of 12:34, 25 May 2016

The fourth intervention to reverse mild Alzheimer's in the Bredesen Protocol is:

Goal: Optimize sleep
Approach: 8 hr sleep per night; melatonin 0.5mg po qhs; Trp 500mg po 3x/wk if awakening. Exclude sleep apnea.
References: Role of melatonin supplementation in neurodegenerative disorders
Improving and Retaining Memory Function Feb 15, 2015

Get at least 7 hours of sleep each night (preferably 8). Taking melatonin before bed can be helpful (0.5 to 1mg; this can be purchased over the counter). If you awaken and can't go back to sleep in the middle of the night, you can add tryptophan (500mg) or 5-hydroxytryptophan (100mg) at bedtime.

Sleep Apnea

The next intervention is Exercise.