Difference between revisions of "ApoE4 Research"

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(Removed old ones and added sites to sign up for research.)
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* Those ε4 homozygotes who are interested in participating in trials could contact researchers and say they are available to be studied (heterozygotes could of course also be studied). Some researchers would jump at the chance to research non-demented ε4 homozygotes, since the expense of finding ε4 homozygotes in younger populations is enormous.
* Those ε4 homozygotes who are interested in participating in trials could contact researchers and say they are available to be studied (heterozygotes could of course also be studied). Some researchers would jump at the chance to research non-demented ε4 homozygotes, since the expense of finding ε4 homozygotes in younger populations is enormous.


Some research teams or organizations that could be contacted:
Additional information about participation in the clinical trial can be found at:
 
* [http://www.alz.org/trialmatch Alzheimer’s Association Trial Match]
 
* [https://www.endalznow.org/GeneMatch GeneMatch]
 
Other research teams or organizations that could be contacted:
 
* [http://www.generationstudy.com Generation Study]


* [http://www.wai.wisc.edu/research/wrap.html Wisconsin Registry for Alzheimer's Prevention (WRAP)]
* [http://www.wai.wisc.edu/research/wrap.html Wisconsin Registry for Alzheimer's Prevention (WRAP)]
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* [http://blog.23andme.com/23andme-research/investigating-the-rare/ 23andMe.]
* [http://blog.23andme.com/23andme-research/investigating-the-rare/ 23andMe.]
Status: [[23andMe]] is not currently pursuing ApoE-related research.
Status: [[23andMe]] is not currently pursuing ApoE-related research.
* [http://www.wearecurio.us/ Linda Avey's Alzheimer's Foundation (still a work in progress).]
* [http://genomera.com/ Genomera, a platform for crowd-sourcing research (still in beta).]


* [http://www.endalznow.org/ Alzheimer's Prevention Initiative]
* [http://www.endalznow.org/ Alzheimer's Prevention Initiative]
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* [http://opensnp.org/ OpenSNP.]
* [http://opensnp.org/ OpenSNP.]
==Interesting Alzheimer's research projects==
* [http://www.mindcrowd.org/ MindCrowd.]

Revision as of 14:33, 26 November 2017

Here are some ideas about what can be done to focus more research on the APOE-ε4 allele and the protein it produces, ApoE4.

  • Encourage researchers to pool existing data to get statistical significance. There are many researchers sitting on unpublished data looking at lifestyle and even drug interventions and their relation to outcomes based on ε4 status. The numbers of ε4 homozygotes in any particular study are in nearly all cases (I'd guess) too small to reach statistical significance, but if the data were pooled it would surely permit some at least tentative, if not solid conclusions. Asking researchers about unreported data on an effect caused by APOE isoform is also a way to raise awareness among them, or to remind them, about how important it is. See "Recent studies that did not report on APOE status."
  • Those ε4 homozygotes who are interested in participating in trials could contact researchers and say they are available to be studied (heterozygotes could of course also be studied). Some researchers would jump at the chance to research non-demented ε4 homozygotes, since the expense of finding ε4 homozygotes in younger populations is enormous.

Additional information about participation in the clinical trial can be found at:

Other research teams or organizations that could be contacted:

Among ADDF's many research efforts is a focus on ApoE. See "Apolipoprotein e4: not just a genetic risk factor"

Status: 23andMe is not currently pursuing ApoE-related research.

ε4 carriers who feel comfortable sharing their data (anonymously) can upload their sequencing and health information to existing open genome projects: